ID A0A3B4BLG3_9GOBI Unreviewed; 1701 AA.
AC A0A3B4BLG3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Voltage-dependent calcium channel alpha-1 subunit IQ domain-containing protein {ECO:0000259|SMART:SM01062};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000029576.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000029576.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR Ensembl; ENSPMGT00000031481.1; ENSPMGP00000029576.1; ENSPMGG00000018971.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF5; VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1036..1054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1151..1169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1248..1271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1408..1442
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 470..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1504..1642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1682..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 430..457
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 501..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1504..1521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1625..1639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 72
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 388
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 929
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1701 AA; 195444 MW; 4200BF6BD698B254 CRC64;
MFAIIGLEFY SGKLHHTCLT VDSSELAFAC GVRKCPDKYD CNDTWIGPND GITQFDNILF
AVLTVFQCIT MEGWTAVLYN TNDALGPTWN WLYFIPLIII GSFFVLNLVL GVLSGEFAKE
RERVENRRAF MKLRRQQQVE RELNGYRAWI DRAEEVMLAE ESKNSGRSPL DERTKVNESG
LLFFFISAYL RRKERMLRIS IRRMVKTDTF YLLVLSLVAL NTICVAIVHH DQPDWLTIFL
YYAEFVFLGL FLAEMCLKMY GLGFRLYFNS SFNCFDCAVI IGSIFEVVWG FFRPGMSFGI
SVMRALRLLR IFKITKYWAS LRNLVVSLMS SMKSIISLLF LLFLFIVVFA LLGMQLFGGR
FIFEDYTPTN FDTFPAAIMT VFQILTGEDW NEVMYNGIRS QGGVQYGMWS SIYFIVLTLF
GNYTLLNVFL AIAVDNLANA QELTKDEEEE EEFFNQRPYL YRKRAIHRGR PNFPDEADGG
TGPPDEQPLN GAKAFANRRE RRRKVNMSVW EQRANQLRKR RQMASREELF SNPTEDTAET
STIPHHGPAL SPMSESEPPM SITIPIPEPP TSEPLVNISE EKTPTSNHRT TGGSRHRMAR
KFRGSEDGAR HRRHRHREAR AEAKSLDCTL APNEGTRVKR SLSQDPRVLD EQDEKEEERE
KTDVVQDEDG TCIVNPYADV GEESRKFVKL SCSVCSIRRI CHYVVNLRYF EMTILLVIVA
SSIALAAEDP VCTNSERNKV LRYFDYVFTG VFTFEMIIKM IDQGLILHDG SYFRDMWNLL
DFIVVVGALI AFALTNVMGN NKGRDIKTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVTS
LKNVFNILIV YQLFMFIFAV IAVQLFKGKF FYCTDSSMKT VTERYCDGYY IDYSRDKKEV
KRREWRRHEF HYDNVCWALL TLFTVSTGEG WPQVLQHSTD VTEENMGPSR GNRMEMSIFY
VVYFVVFPFF FVNIFVALII ITFQEQGDKM IQECSLEKNE RACIDFAISA KPMTRYMPQN
RQTVQYRLWH FVASPSFEYT IMVMIALNTV VLMMKYHSAP TAYDYVLKHL NTAFTVLFSM
ECILKIMAFG FVNYFRDTWN IFDFITVLGS ITEISVNTIN MSFLXXXXTK VLRQGYTIRI
LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIKLN DDSHINQHNN FKTFFSALML
LFRSATGESW QEIMLSCLSG QECEPDPSLA PFTMSPDHEG GCGTDFAYCY FVSFIFFSSF
LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EFVRIWGEYD RLACGRIHYT AMYEMLTHMS
PPLGLGKKCP AKIAYKRLVL MNMPVDEDMT VHFTSTLMSL IRTALDIKIA RGGEDRIALD
SELQKEISII WPYLPQKTLD LLVPINKDTD MTVGKIYASM MIMDYFKQNK AKKLRQQLEA
QVLCCSRVTS RVRRECTGPA TRATRPLVSD VTPVRRPPLN THLFILCHCP HLLCVTAPPV
SRSERQHAER ERRHLLSPDR SRCNSADRSQ QPSRSSSVER GNSSDSPVPS TSESSTPSGR
RPMSRPHISY SPLASRPQPE DEDEPGSPET IRRVKSKRES KESKGERRRN PSPPRRYPSE
PFLASQEQDD EQSPDPTGPI ETLTFEAAVA CSLGRSNTIN IGARSRTGWQ VPNGHFRKRL
AQTTSVTGCD PLSDTEEDDR C
//
