ID A0A3B4BPI2_PYGNA Unreviewed; 178 AA.
AC A0A3B4BPI2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1B {ECO:0000256|ARBA:ARBA00020090};
DE AltName: Full=DARPP-32 {ECO:0000256|ARBA:ARBA00029874};
DE AltName: Full=Dopamine- and cAMP-regulated neuronal phosphoprotein {ECO:0000256|ARBA:ARBA00030254};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000001488.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000001488.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1.
CC {ECO:0000256|ARBA:ARBA00002900}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000256|ARBA:ARBA00007775}.
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DR RefSeq; XP_017578260.1; XM_017722771.1.
DR AlphaFoldDB; A0A3B4BPI2; -.
DR STRING; 42514.ENSPNAP00000001488; -.
DR Ensembl; ENSPNAT00000012076.1; ENSPNAP00000001488.1; ENSPNAG00000008190.1.
DR GeneID; 108442635; -.
DR CTD; 84152; -.
DR GeneTree; ENSGT00730000111283; -.
DR OMA; VYPHMEE; -.
DR OrthoDB; 4018581at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417:SF2; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B; 1.
DR PANTHER; PTHR15417; PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT REGION 127..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..171
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 178 AA; 20336 MW; 9EB6AF66F1026C86 CRC64;
MDTSGPEDVP VEPKERKKIQ FAVPSTAPTQ LDPRQVEMIR RRRPTPATLF RVADQTSPED
DNSTHQWVVG ENGVLKPKRV NPSVYQPPSL KAVQQMAEAQ MQKLGVYPHM EEEGEEPLET
EEAELLRCTA DSQGEGVRDD RPESSKLMTT ERTEEEDEEE EEEEKEEETT EDESRNVE
//
