ID   A0A3B4BQG7_PYGNA        Unreviewed;       258 AA.
AC   A0A3B4BQG7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Acid-sensing ion channel 2 {ECO:0008006|Google:ProtNLM};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000001853.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000001853.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A3B4BQG7; -.
DR   STRING; 42514.ENSPNAP00000001853; -.
DR   Ensembl; ENSPNAT00000011436.1; ENSPNAP00000001853.1; ENSPNAG00000000971.1.
DR   GeneTree; ENSGT00940000154991; -.
DR   OMA; WLAFPTH; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|RuleBase:RU000679}.
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  29188 MW;  5DD5BCFFE37BD978 CRC64;
     LQWLGNKREE KRERGPCPSD PEPAPAPSTS SSPPHLASRR RHQARPGTPR ASATPSQQLP
     TLALLARTRL HGLRQACTPA SSVGRRAFWT LALCTSMGLL LSWSSNRLLH WLAFPTHTRV
     HTEWARELAF PAVTICNNNP VRLYRLTKSD LYFAGHWLGL LLANRTARPL VLDLLHEDRR
     AWFRKLSDFR LFLPPRHFEG TSLEFMDRLG HQLEDMLLGC KYRGEPCGAH NFSTVSVSLS
     FSLAKSLSIH LSISSPWF
//