ID A0A3B4BQP3_PYGNA Unreviewed; 355 AA.
AC A0A3B4BQP3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Left-right determination factor 2-like {ECO:0000313|Ensembl:ENSPNAP00000002022.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000002022.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000002022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_017575702.1; XM_017720213.1.
DR AlphaFoldDB; A0A3B4BQP3; -.
DR STRING; 42514.ENSPNAP00000002022; -.
DR Ensembl; ENSPNAT00000011160.1; ENSPNAP00000002022.1; ENSPNAG00000008516.1.
DR GeneID; 108440979; -.
DR CTD; 30145; -.
DR GeneTree; ENSGT00390000010056; -.
DR OMA; VSVYWVQ; -.
DR OrthoDB; 5391376at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF037402; TGFb4; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..355
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017257415"
FT DOMAIN 245..348
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 355 AA; 39941 MW; A2DB97C389672953 CRC64;
MAPCLVLCAL LLAVAEGFTH EDMKGAMLKQ LGLSEVPKIH KRDVENMVVP AHVKTKYLNL
LKVHNKRRRR SLPSLAGILR GIPGNADISG EFVYSDTTRQ RVVFEMDSRI PENSEVTMAE
LKLYKKAPHK RSMPVRKGQR PVNNARVSIY WVEVLESGGN RTSLVDSRLV PIHETGWKSF
DVTQAVHYWS RSQQKTPMHL EVWIEGERPG SYAAEMAKSV HFTGQDPSDN TLGKPELVLY
TLNLEEYGSN GDCAGGSAGG RCCREEYFIN FRALTWTQYW IIEPAGYQAF RCGGRCRQPE
RSYGYGERRC AVAESAPLPM MYLVKKGDYT EIEVAEFPNM IVEKCGCAVD NISVV
//
