ID A0A3B4BR28_PYGNA Unreviewed; 400 AA.
AC A0A3B4BR28;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|Ensembl:ENSPNAP00000002078.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000002078.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000002078.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_017546411.1; XM_017690922.1.
DR RefSeq; XP_017546412.1; XM_017690923.1.
DR RefSeq; XP_017546413.1; XM_017690924.1.
DR RefSeq; XP_017546414.1; XM_017690925.1.
DR AlphaFoldDB; A0A3B4BR28; -.
DR STRING; 42514.ENSPNAP00000002078; -.
DR Ensembl; ENSPNAT00000011055.1; ENSPNAP00000002078.1; ENSPNAG00000008552.1.
DR GeneID; 108423540; -.
DR CTD; 652; -.
DR GeneTree; ENSGT00940000159502; -.
DR OMA; HEEHMEQ; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..400
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017235434"
FT DOMAIN 284..400
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 276..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..297
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 45679 MW; C0DE778595AABCC9 CRC64;
MIPGNRMLMV ILLCQVVLGE SNHASLIPEE GKKKVSGHHP GQSHELLRDF EATLLHMFGL
QRRPRPSRSA VVPQYLLDLY RLQSGEADEA GAQEVSFEYP ERSTSRANTV RAFHHEEHME
QVQSDGPYTT GTPLRFLFNL SSIPEDELLS TAELRLYRKQ IEEASSEDAG NEGLHRINVY
EVLKPPRPGQ LITRLLDTRL VHHNTSNWES FDVSPAVLRW TRDRLPNHGL AVEVLHLNRT
LRHQDKHVRI SRSLHQAPGE DWDQLRPLLV TFGHDGKGHP LTRRTKRSPK QRGRKRNRNC
RRHALYVDFS EVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNSNI
PKACCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR
//