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Database: UniProt
Entry: A0A3B4BR28_PYGNA
LinkDB: A0A3B4BR28_PYGNA
Original site: A0A3B4BR28_PYGNA 
ID   A0A3B4BR28_PYGNA        Unreviewed;       400 AA.
AC   A0A3B4BR28;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|Ensembl:ENSPNAP00000002078.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000002078.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000002078.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   RefSeq; XP_017546411.1; XM_017690922.1.
DR   RefSeq; XP_017546412.1; XM_017690923.1.
DR   RefSeq; XP_017546413.1; XM_017690924.1.
DR   RefSeq; XP_017546414.1; XM_017690925.1.
DR   AlphaFoldDB; A0A3B4BR28; -.
DR   STRING; 42514.ENSPNAP00000002078; -.
DR   Ensembl; ENSPNAT00000011055.1; ENSPNAP00000002078.1; ENSPNAG00000008552.1.
DR   GeneID; 108423540; -.
DR   CTD; 652; -.
DR   GeneTree; ENSGT00940000159502; -.
DR   OMA; HEEHMEQ; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..400
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017235434"
FT   DOMAIN          284..400
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          276..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..297
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  45679 MW;  C0DE778595AABCC9 CRC64;
     MIPGNRMLMV ILLCQVVLGE SNHASLIPEE GKKKVSGHHP GQSHELLRDF EATLLHMFGL
     QRRPRPSRSA VVPQYLLDLY RLQSGEADEA GAQEVSFEYP ERSTSRANTV RAFHHEEHME
     QVQSDGPYTT GTPLRFLFNL SSIPEDELLS TAELRLYRKQ IEEASSEDAG NEGLHRINVY
     EVLKPPRPGQ LITRLLDTRL VHHNTSNWES FDVSPAVLRW TRDRLPNHGL AVEVLHLNRT
     LRHQDKHVRI SRSLHQAPGE DWDQLRPLLV TFGHDGKGHP LTRRTKRSPK QRGRKRNRNC
     RRHALYVDFS EVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNSNI
     PKACCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR
//
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