ID A0A3B4BR65_PYGNA Unreviewed; 2158 AA.
AC A0A3B4BR65;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTBN1 {ECO:0000313|Ensembl:ENSPNAP00000001080.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000001080.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000001080.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR Ensembl; ENSPNAT00000012769.1; ENSPNAP00000001080.1; ENSPNAG00000007975.1.
DR GeneTree; ENSGT00940000154864; -.
DR OMA; EGEGMIA; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21248; CH_SPTB_like_rpt2; 1.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF226; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 1; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 17.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR002297};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 53..157
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 172..277
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 2087..2110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 456..490
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 990..1024
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1096..1123
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1421..1448
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2087..2103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2158 AA; 250972 MW; 5DB7B7D5450B72D6 CRC64;
MTTVAAEYDH MDIQQQYQDT VNNRWDEDWD NENSSARLFE RSRIKALADE REAVQKKTFT
KWVNSHLARV SCRITDLYMD LRDGRMLIKL LEVLSGERLP KPTKGRMRIH CLENVDKALQ
FLKEQRVHLE NMGSHDIVDG NHRLTLGLIW TIILRFQIQD ISVETEDNKE KRSAKDALLL
WCQMKTAGYP NVNIHNFTTS WRDGMAFNAL IHKHRPDLID FDKLKKSNAH YNLQNAFNLA
EQHLGLTKLL DPEDISVDHP DEKSVITYVV TYYHYFSKMK ALKVEGKRIG KVLDNAIETE
KMIEKYESLA SDLLEWIEQT IIILNNRKFA NSLVGVQQQL QAFNTYRTVE KPPKFTEKGN
LEVLLFTIQS KMRANNQKVY MPREGKLISD INKAWERLEK AEHERELALR NELIRQEKLE
QLARRFDRKA AMRETWLSEN QRLVSQDNFG FDLQAVEAAT KKHEAIETDI AAYEERVQAV
VAVARELEAE NYHDIKRITA RKDNVLRLWD YLLELLKARR QRLEMNLGLQ RVFQEMLYIM
DWMDEMKMLL LSQDYGKHLL GVEDLLQKHA LVEADIGIQA DRVRAVNANA QKFAVSGDGY
KPCDPQVILD RVAHLEFCYQ ELTQLAAERR ARLEESRRLW KFFWEMAEEE GWIREKEQIL
SSDDVGKDLT GAVRLLSQHR ALEDEMSGRA GHLQHTVREG LAMADAGHFG EDRIRERVAE
VQAQWAALER LAAVRKARLE EACGLHQFQT DADDVDAWTL DALRIVSSGD VGHDEFSTQA
LVKKHKDAAA EVASYRPVID ALQEQGRALP PELAESADVS GRLVGIEERY KEVAELTRLR
KQALQDALAL YKMFSEADAC EVWIDEKEQW LNSMEIPEKL EDLEVIQHRF ESLEPEMNNQ
ASRVAVVNQI ARQLIHSGHP SEKDIKAQQD KLNTRWSQFR DLVDQKKESL NSALGVQNYH
LDCNETKSWI REKTKVIEST QELGNDLTGV MALQRKLTGM ERDLAAIEAK LGDLRGEAER
LAEEHPEQAK AITGRLAEID AVWEEMKATL HNREASLGEA SKLQQFLREL DDFQSWLSRT
QTAIASEDMP NTLAEAEKLL AQHEGIKNEI DNYEEDYQKM RDMGEMVTQG QTDAQYMFLR
QRLQALDTGW NELHKMWENR QNLLSQSHAY QLFLRDTKQA EAFLNNQEYV LAHTEMPTTL
EGAEAAIKKQ EDFMTTMDAN EEKINSVVEA GRRLASDGNI NAERIQERAS SIDDRHKKNR
EAAVELLMRL KDNRDLQKFL QDCQELSLWI NEKMLTAQDM SYDEARNLHS KWLKHQAFMA
ELQSNKEWLD KIEKDGMQLV SEKPETEAVV KEKLATLQKQ WQELESTTQT KAQCLFDANK
AELFTQSCAD LDKWLGGLEG QIQSDDYGKD LTSVSILLKK QQMLENQVEV RKREVEELQS
QAHVLQQEGK DTDEVDRRRQ VVEKKFQELL DPLMKRKNFL MASREIHQFN RDVEDEILWV
EERMPIATST DHGHNLQTVQ LLIKKNQTLQ KEIQGHQPRC DDIFERSQSI LKEDSPNVEV
IRARLDDLQT LWSLLIQETE KRHERLEEAH KAQQYYFDAA EAEAWMSEQE LYMMSEEKAK
DEQSSVTMLK KHQILEQAVE DYAETVHQLS KTSRDLVAAN HPESERIGMR QSQVDKLYAG
LKDLSEERRG KLDERFRLFQ LNREVDDLEQ WIAEREVVAG SHELGQDYEH VTMLQERFRE
FARDTGNIGQ ERVDAVNRMA DELINAGHAD AATVAEWKDG LNEAWADLLE LIDTRTQILA
ASYELHKFYH DAKEILSRIL DKHKMLPEEL GRDQNTVETL QRMHTTFEHD IQALGTQVRQ
LQEDAVRLQS AYAGDKADDI QRRESEVLDA WRNLLEACEG RRTRLLDTGD KFRFFSMVRD
LMLWMEDVIR LIEAQEKPRD VSSVELLMNN HQGIKAEIDA RNDSFTSCIE LGKSLLARKH
YASEEIKEKL LQLTDKRKDM IDKWEDRWEW LRLILEVHQF SRDAGVAEAW LLGQEPYLSS
REVGQSVDEV EKLIKRHEAF EKSAATWEER FSALERLTTM ELLEVRRQQE EEERRRKPPT
PEPAQEIQEH TQQASLVIRV YRALTKPLPR KKVIYIHPGS SLLEGIHLCR VCVWVFAN
//
