ID A0A3B4BRI4_PYGNA Unreviewed; 1370 AA.
AC A0A3B4BRI4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Partitioning defective 3 homolog {ECO:0000313|Ensembl:ENSPNAP00000001101.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000001101.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000001101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_017559890.1; XM_017704401.1.
DR Ensembl; ENSPNAT00000012730.1; ENSPNAP00000001101.1; ENSPNAG00000000563.1.
DR GeneID; 108431315; -.
DR CTD; 101882925; -.
DR GeneTree; ENSGT00950000183214; -.
DR OrthoDB; 5405986at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF18; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 273..348
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 496..570
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 612..687
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 81..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..405
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1345
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1370 AA; 151253 MW; EE15785A8BAB2BE1 CRC64;
MKVTVCFGRT RVVVPCGDGN IKVHSLIQQA AMRYKKAIAK DPGYWIQVHR LEHGDGGILD
LDDVLCDVAD DKDRLVAVYE EQDPHHGGDG TSASSTGSQS PDVFSRGELS SNSPSAFQPY
HNSSEIEVTP SALRTNMPLH VRRSSDPALV ALTESALQPD EPSRKNPSRW STTAGFLKPN
ATSGTNSLER KGKGPASYRS LPRDTAAWAS QFQRESARSS LSANHPMVDR WLVRQEQDDE
DEERRRDEGR NGRIEPVGRA DSCVESLSLE DMLKPVEVSN GGGPLGIHVV PFSSRDRRTL
GLLVKRLEKG GKAEREALFQ ENDCIVRINN HDLRNIRFEQ AQNLFRQAMR SPLILFHVVP
AVKKPLYEQL SQCEFGLQSG PSPEPGPGPS GFTPDPKPGP APSRLTPDHK PGDRGSLVVG
SINYSPQRMS KTGPHPNLNH QPLPVHPEQN KAHSTLPAVG ITPPAKSPLE GPAQPLKTAT
PTTSTGFSKK IGRKFNVQLR KGPEGLGFSI TSRDVPIGGS APIYVKNILP RGAAIQDGHL
KAGDRLLEVN GVDLNGKSQE EVVALLRSTP MGGTVSLLVV RQEDAFLPRE VKAEDDDLVL
TPDGTREFLT FEIPLNDSGS AGLGVSVKGN RSKENHADLG IFVKSIINGG AASKDGRLRV
NDQLIAVNGE SLLGKTNQEA METLRKSMSV ESNKRGMIQL IVARRVNGRN EEDAPENPSA
SDVPLGRPRE ELERRISHSL YPGAIEGLDD TLSPRLSITG RMMGNYQLSP TVNMPQDDTV
IIEDDRPPVL PSHLSDQSSS SSHDDMGFVT DVPASWAKDI QNQDECSLSP DADPDGAFQR
EGFGRQSMSE KRTKQYGDAT QLEIIKTRKS KSMDLGNSTR DVGPNLGLKK SSSLESLQTA
VAEVTLNGDV PFHRPRPRII RGRGCNESFR AAIDKSYDRP VMSMAGEEEE DEGMETLEED
TEESSRSGRD SVSTANDLPL PAGGAAIPES QVNGGQSKDD KKKGGKEKKE KNKSKKGVLK
GLGDMFRFGK HRKDERTGDK VERKGSSKNK MEDTQATEEE MQRMRLERER IQAKTRELRE
RQARERDYAE IQDFNRTFSS DEEHTYAGIG SLDSSMDSSQ SLNQQPPGQE RPQSPREQPL
EALYAQVNKP RNCRPPSADS NRLAPSNHDR IQRLRQEFQQ AKQEEEPDDR RRTYSFQQQP
WANAGAYSPT GRHSVSVEVQ MQRQRQDDRD AFTQSQRQYN SLPRQPRKNP STISQDSWDK
VYPPGEVFQS AKENPRYSSY QGGRGTNGYL STPVSGLNAR VLLETQELLR QEQRRKEQEA
QAKLAPSPDP PAVAPTPPKG PYRQDVPPSP SQLARLNHLQ SPEKGRPFHS
//
