ID A0A3B4BSF4_PYGNA Unreviewed; 1457 AA.
AC A0A3B4BSF4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Collagen type IV alpha 1 chain {ECO:0000313|Ensembl:ENSPNAP00000002578.1};
GN Name=COL4A1 {ECO:0000313|Ensembl:ENSPNAP00000002578.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000002578.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000002578.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR STRING; 42514.ENSPNAP00000002578; -.
DR Ensembl; ENSPNAT00000010184.1; ENSPNAP00000002578.1; ENSPNAG00000009000.1.
DR GeneTree; ENSGT00940000157678; -.
DR OMA; MIPPCPQ; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023:SF1019; COLLAGEN; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 9.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1234..1457
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 1..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..157
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..464
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..555
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..662
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1223
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1457 AA; 142013 MW; B70901A40749E73E CRC64;
RGFPGLQGNM GFPGMQGHEG PPGPMGPKGD LGEPGAPGIK GARGPPGAAG FPGNPGLPGL
PGQDGPPGPS GIPGCNGTKG ERGIDGISGL PGLQGPPGDP GGFIGGILPQ KGEKGFQGQP
GLPGSPGNPG PQGLLGPPGP PGLKGYAGPP GPPGPPGTLM FMGAKGDKCS VYDAGIKGEP
GPPGPPGKAG KDGQDGAEGG KGDPGFPGHN GLKGDKGERG PPGYGDGAPG PPGPPGFPGP
QGERYPGQPG DPGPPRHLEG PPGERGFPGE IGQKGDKGVD GEPLRGPPGA DGAAGPPGPP
GPLPPGPPGL QGEIGQKDQG DTCTQCSAFG PPGLPGAPGP KGQQFPGPAG SKGEKGQPGP
VGVPGDPGSD GSPGLMGAPG AQGAPGDIYL APHLKGEKGL SGLPGSRGLP GINGLPGKDG
RPGQPGPKGE PARVGIKGER GPDGDPGTPG PPGERGPPGL PGIGRPGEPG EKGSPGQPGV
PGRQGIPPKG DPGKGVSSPG PQGPPGPRGE SGIPGLQERG PPGDQGLPGF PGLKGDPGLP
GIGLPGPPGP KYSGIPGAPG LPGEPGRPGQ DGIPGIPGTA GQKGEPAIGL RGPKGSIGQP
GVPGFPGEKG NVGMPGVPGT EGHTGPPGAQ ERGPPGAHGL AGPPGPPGPG EPGLPGPMGP
TGKPGPFQIG EKGEKGLPGL PGPAMPGPKG EKGTPGLPGF PGPKGLPGET GHPGQDGMPG
ERPKGEMGIM GAPGSPGFQD PGFTGPRGEF GEPGPKGERG EQGERGPPGN MTEVDMENMK
GEKGDTGDRD PGPTGDRGYP GADGDPGMPG KDGMPGTPGQ PVGGPKGSKG TSGTPGHHGF
KGTEGPKGDK GVAGLPGIGI PGLPGEKGEI GQPGFPGESG QKGVKGAMGI PGSPGSPGPK
GDIGPISPGV PGEKGVVGLP GSPGESGFPG RPEPGLQGPP GPHGEKGDPG IDGIPGSSGE
RGDPVPGRGF PGTPGQLGIK DRGNPGLPGT PGIPGIPGTK GEKGLPGLEG IQGQPGERGL
PGPSMQGPKG DRGAPGEPGE PQIGAPGPTG VPGSPGVKGE RGNQGFTGPQ GTQGLKGDKG
FTGLPGEPGL PGYNGPKGEM GIQGVPGFPI KGELGHVGVK GEAGDRGFPG VKNEGPPGTP
GTNTFIKGDI GFPGPQGPAG LPGAQGYPGA KGQQLMGIQG IKGEDGEPGY NGLPGAKGEP
GPVGPAPRGY PGPPGPDGIP GQVGPPGPSS MDHGFLVTRH SQSVDVPLCP QGTTLIYDGY
SLLYVQGNER SHGQDLTAGS CLRKFSPMPF LFCNINNVCN FASRNDYSYW LTSPEPMPMS
MAPVTGDSIK PFISCAVCEA PAMVIAVHSQ TVAIPPCPHG WISLWIGYSF VMQHTSAGAE
GSGQALASPG SCLEEFRSAP FIECHGRGTC NYYANSYSFW LATIEDEEMF RKPVPTTLKA
GNLRTHISRC QVCMKRT
//
