ID   A0A3B4BVW3_PYGNA        Unreviewed;      1910 AA.
AC   A0A3B4BVW3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=SET binding factor 1 {ECO:0000313|Ensembl:ENSPNAP00000002721.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000002721.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000002721.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   RefSeq; XP_017554452.1; XM_017698963.1.
DR   Ensembl; ENSPNAT00000009964.1; ENSPNAP00000002721.1; ENSPNAG00000009463.1.
DR   GeneID; 108428171; -.
DR   CTD; 6305; -.
DR   GeneTree; ENSGT00940000155263; -.
DR   OrthoDB; 3195274at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13340; PH-GRAM_MTMR5; 1.
DR   CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR022096; SBF1/SBF2.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF12335; SBF2; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          6..456
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          1133..1637
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   DOMAIN          1804..1908
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   1910 AA;  215647 MW;  F32926A8E6C7F574 CRC64;
     MARLADYFVV VGYDLDKRGG SEGQGRILQR FPEKDWEDNP FPQGIELFCQ PSGWQLVPER
     LPASFFVAVL TDINSERHYC ACFTFWETVE NPQLQKEEPS EADEDETPEL LQPAQLYAPK
     SLVLVSRLDH TEVFRNCLGL IYTVHVDSLN VPLETVIGNL LTCVIPIAGG SQINDPPVCS
     LSDWLLGCFQ PDQEDREEGL RTITLGAGDR QVIQTPINDS LPVSGCSVAQ LFRQLGIVNV
     LCLFCAALTE HKILFLSKSY QRLTDACRAL LAIMFPLKYS FTYVPILPGK LLEVLSTPTP
     FIIGVNSFFR SETQELLDVI IADLDGGTVT IPECVHISLL PEPLLQHTQT VLSMVLDPEL
     EVADYAFPPS STQPSALRIQ DKEIRAVFLW LFAQLFLGYR WCLHIIRIHP EPVIRFHKAA
     FLGHRGLSED DFLMKVLDGM AFAGFVSERG APYRTTDLFD DLIANQVERI RQEQGDPHKV
     MNHIKELAEH LFKNENPYPA VAMHRVQRPA DSPHSRSHAS QALFPQLDDV AVQLFIDHAA
     AKLKTAPPVV KAELKEMVPS GPPLADTVDK NGSVLANSAR RLEVVRNCIN YIFDNKMLEA
     KKLMPAVLRA LKGRAARVCL TQELNQHVLQ NRAVLDDQQF DYIVRMMNCT LQDCSHIDEH
     GIAAALLPLV AAFCRKLGGG ITQFAYSCVQ EHMVWTNMQF WEAMFYSDVQ NHIRALYLET
     EDGGAPDEEG TSGLKQVSAL ELASEQTRLW PTLTKESQQE RVQKEESTVF SQAIHYANRM
     SYLLLPLDTS KNRLLRTTGL ADVESVSNSY VTNSIAGSMA ESYDTESGFE DAESSDVANS
     VVRFINRFVD KVCNESGVTN EHLKALHTMI PDIVQMHIET LDAVYRESKR LPPIQKPKLL
     RPTLLAGEEF VMDGMRVHLV SDGREEATGV MGGPPLLPAE GAIFLTTYRI IFKGMSIDPL
     VGEQVVTRSF PIASLTKEKK ISVHIPMDQF IQEGLQLRSC TFQLMKIAFD EEVASDLAEV
     FRKHMHKLRY PQHVQGTFAF TVGQSAKLVV EHKTKDKNQS LKTLSKNLVK SAKRTIGRQY
     VTRKKYTPPT WENRSSLQSE MDEDEISVSE ELEQSALTLS STIRSSDRQT MSNVVERACC
     RDYQRLGLGT LSNSLTRSKN EPFRISTVNR MYTVCRSYPG LLIVPQSIPD STIQRISRCY
     RQNRFPVVCW RNSRTKAVLL RSAGLHAKGV VGFFKSPNAP SAGPSQADST SLEQEKYLQA
     IISSMPSYNE ASGRNTLSGF TSTHMSTSDS SDKLRQPKIG VLMKQVLGTK EDLPGTFSRG
     GKWGSIRGSG RLSAYNPDVG NRLAGKESPQ ANGGPAEPYF LRQQRAYLYI IGDKSQLKGG
     KQDSFQQWEV VPIEVFDVRQ VKNSFKKLMK ACVPSSPSSE PNMSFHRCLE ESDWMNLLHK
     VLQVSVLVVE LLATGSSVMV SLEDGWDVTT QVVSLVQLLS DPYYRTFDGF RLLVEKEWLS
     FGHRFSHRGA QTLASQSSGF TPVFLQFLDC VHQIHLQFPM EFEFSQYYLK FLAYHYVSNR
     FRTFLLDSDY ERIELGVLYE EKGERRTPQV CKSVWDYIDR LHKKTPIFYN YMFSPEEEEV
     LRPYSFISNL KVWDFYTEET LSEGPSYDWE LVRGRPEGHT EDTATDRPET AAPKSQRRVV
     WPCYDSLSKV LPDAITKLLQ DVHNLEAELG HVSEKWKDTW DKIKTTQRTE TKLESRHSFS
     SSLLMSSNLI HQRRSQGMYL QESGVGSSIN LALDCEASAT STPASGRPST SNLYSQFQST
     ESENRSYEGI LFKKGALLKP WKPRWFVLDK TKHQLRYYET RQDKECKGVI ELAEVESVIP
     GTPAMGAPKN VEEKAFFDLK TTKRVYNFCA QDSQNAQLWM DSIQSCLSDA
//