ID   A0A3B4BW21_PYGNA        Unreviewed;       493 AA.
AC   A0A3B4BW21;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Cyclic GMP-AMP synthase {ECO:0000313|Ensembl:ENSPNAP00000002699.1};
GN   Name=CGAS {ECO:0000313|Ensembl:ENSPNAP00000002699.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000002699.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000002699.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the mab-21 family.
CC       {ECO:0000256|ARBA:ARBA00008307}.
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DR   AlphaFoldDB; A0A3B4BW21; -.
DR   Ensembl; ENSPNAT00000009984.1; ENSPNAP00000002699.1; ENSPNAG00000009093.1.
DR   GeneTree; ENSGT01050000244827; -.
DR   OMA; EHYFIPG; -.
DR   Proteomes; UP000261440; Unplaced.
DR   Gene3D; 1.10.1410.40; -; 1.
DR   Gene3D; 3.30.460.90; -; 1.
DR   InterPro; IPR024810; Mab-21-like.
DR   InterPro; IPR046903; Mab-21-like_nuc_Trfase.
DR   InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR   PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR   PANTHER; PTHR10656:SF35; CYCLIC GMP-AMP SYNTHASE; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   Pfam; PF20266; Mab-21_C; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   3: Inferred from homology;
FT   DOMAIN          214..360
FT                   /note="Mab-21-like nucleotidyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF03281"
FT   DOMAIN          374..475
FT                   /note="Mab-21-like HhH/H2TH-like"
FT                   /evidence="ECO:0000259|Pfam:PF20266"
FT   REGION          19..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   493 AA;  56423 MW;  0B0D67E02D9BFD0B CRC64;
     IVPMHRKTLR MSEEVLLHAM SGRGKKVDER PRAKAPGSGR RKSSAKAEEQ KRASADVEAP
     TEVKKKPEQQ KKGEEKKHAD NKARGGAQPR DTRPPASSEP LCASNDQPCI AKSAEVKKVP
     RGPPKKGNSM DGNPARILQD TLEKLKIRKN QKNEVAKYVN DIHGAINKHV EVSLSWCKRI
     QVLKTGSYYE NVKVSHLGDC WLTVMVFLLI LDIQPFGEDG AFYSVAVKRH SKHPLDRFLN
     EDKTIKASEM LKEFRDKVKE AAAKLPYDVT VDRKKQGCPA VTLQVKKGDT LISLDFVLGL
     EVHSSSWPHF TNDGFKIDNW LGKKVKRDLK YKPYYLVSKY QGRDAWRISF SHVEKEILKN
     HGHSKTCCES QPCCRKQCLK LLKYLVQRLK EMYPKEAAKL CSYHAKTTLL HACANRVEDS
     EWAADQLSHC FQLLLHDFEE HLRKQHLPNF FVPSHNLLKS AGMDKKSCNL LADYIEYERN
     NGFPLFREFY LFF
//