ID A0A3B4BWY3_PYGNA Unreviewed; 1453 AA.
AC A0A3B4BWY3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=ERBB3 {ECO:0000313|Ensembl:ENSPNAP00000003025.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000003025.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000003025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017553359.1; XM_017697870.1.
DR STRING; 42514.ENSPNAP00000003025; -.
DR Ensembl; ENSPNAT00000009448.1; ENSPNAP00000003025.1; ENSPNAG00000009388.1.
DR GeneID; 108427608; -.
DR CTD; 386635; -.
DR GeneTree; ENSGT00940000156107; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00064; FU; 3.
DR CDD; cd12095; TM_ErbB3; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF88; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1453
FT /note="Receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017378408"
FT TRANSMEM 654..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 724..981
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1125..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 730..738
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 757
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1453 AA; 161895 MW; BC78DA9C9E142363 CRC64;
MSASRLQVLA LCLALLWFPQ SARTQTQEGK PAMCLGTQNM LSVTGSSEVQ YQRMKEMYMD
CQIVMGNLEI THMEHYRDFS FLQSIREVTG YVLIAINQFR QLPLENIRVI RGTSLYEERF
ALAVLVNYQK DGDYGLQELG LTHLTEILEG GVQIIQNKFL SYVPQINWLD IVKDSGAEVI
IKDNGPDKPC HESCDGPCWG PGRESCQTLT KTVCAPQCNG RCFGRNPSEC CHIECAGGCT
GPLDTNCFAC RNFNDSGSCV PQCPQGLIYN KVTFKLEPNP NAKYQYGSVC VAQCPPNFVV
DGSSCVSSCP SDKTEADKKG VKRCEPCGGL CPKVCEGTGA ANRQTVDSKN IDSFINCTKI
QGSLHFLITG IKGDRFNNIS ALDPKKLQIF NTVREITDFL SIQSWPEEMD DLSVFSNLTT
IQGRSLYKGV TSKRGYALLV MRITTLKSLG LRSLKKISDG GIYITGNSKL CYHHTVNWTR
LFGTGARAQR RQKSIDIKEN RHQDECINEG HVCDPLCSSD GCWGPGPDQC LSCKNFSRGG
TCVPHCNFLE GERREFAGPN GECMLCHSEC AVQESRLTCR GPGADQCEVC VRLQDGPHCV
SSCPEGVMGE NGLVIYKFPN AQRKCQPCHA NCTIGCTGPG LRDCVESSRS APGLPVTAIV
LGAIAAVLIG FSVFVMTVLY RRSLAIRRKR ALRRYLQSGE SFEPLDPGEK GTKVHARIFR
VSELRKIKLL GSGVFGTVHK GAWIPEGETI KIPVAIKTIQ DRTGRQTFQE VTDHMLAMGS
LDHPYVVRLL GICPGTSLQL VTQLSTQGSL LEHIRRHKNS LNPQRLLNWC VQIAKGMYYL
EEQRIVHRNL AARNILLKSD FMVQITDYGI ADLLYPDDKK YFYNEVKTPI KWMALESILF
RRYTHQSDVW SYGVTVWEMM SYGAEPYASM RPQEIPDLLE KGERLSQPQI CTIDVYMVMV
KCWMIDENVR PTFKELANEF TRMARDPPRY LVIKQGECTA PDPGSDEAHQ LGNEMDILAV
GLEDQEEEVL DEGMATPPVY LTPSRSLSRL RVDTHRATFT PSCPAGYLPM TPSVEGSMQT
VWPPRSRLNS ARTVSESSEG RGTVVEMEMN EDFASVGSLR RVRHREDSAY MSQRDSLSGP
PDTPIPDTPS PCTEGEEDQN GYVLPGLCDS PLRETVLSMA SHVRLSQGRL SKGRSHELLE
EHDSAEEEYE YMNNQSLPLR RIPGQKRSCC QRTSKRSSTS NPSWGDSMHK SACASYPNKR
SSMEDSESSG GVSQSSSDER SRSDAELLSS EAEYAEADLD QEHQYEYMDI RSGLGHAAAS
IPHRAEHLRP DAYISPKKSM EEDEEEEEEY QYTNQQPRLR RSLMLQGLIG GEGEVYEYEE
MDSLAVGGSS GAEYQNLQEA GEREATGQLH SGIVPYVQVR AGLLVASEGG DRCFDNPDYW
HSRMYSKANA VST
//
