ID   A0A3B4BWZ7_PYGNA        Unreviewed;       851 AA.
AC   A0A3B4BWZ7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=PMS1 homolog 2, mismatch repair system component {ECO:0000313|Ensembl:ENSPNAP00000003040.1};
GN   Name=PMS2 {ECO:0000313|Ensembl:ENSPNAP00000003040.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000003040.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000003040.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   AlphaFoldDB; A0A3B4BWZ7; -.
DR   Ensembl; ENSPNAT00000009407.1; ENSPNAP00000003040.1; ENSPNAG00000009471.1.
DR   GeneTree; ENSGT00940000155381; -.
DR   OMA; RMRIIGQ; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          221..358
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          667..811
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          496..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  95134 MW;  C71DEEBE022A5424 CRC64;
     KWRVEEPAGA IKAIDRHSVH QICSGQVVLS LATAVKELVE NSVDAGATNI KLKDHGTELV
     EVSDNGRGVE EENFEGLTLK HHTSKLRDFS DLIHVETFGF RGEALSSLCA LSDLSVVTCH
     ENSNVGTRLV YDHDGRLVQR APHPRQQGTT VSLQQLFSTL PVRHKEFQRN IKKEYSKMVH
     VLQSYCIIST AVRITCTNQI GQGKRNTVLC TSGSHSMRDN IGALFGPKQL QSLIPFQQIS
     PTDNIKEDYG LSGAELPKDL FTISGYVSQA DHGVGRSATD RQFFFINKRP CDPSKVSKLV
     NEVYHMFNRH QYPFVALNIS VASECVDVNV TPDKRQIFLQ EEKLLLAVLK SSLIAMYETG
     VNKISLNHTP QLSSSMLHLS ILFFSSLPEI TLENNSDTLT QAPKPSFNLA GLKAAFSKHQ
     APGILTKTSN YKPVSNGPAQ KKMQSFFHCS EKLNYVRPSV GSPSSTSFEN AASPLKASTS
     CLNKYEHSLD IAAESGISEE GSSRTPESLC GHGSELSSLS SVLDEHSIKT EPYSELTAKD
     SDVLESSEQE SESIHSPERT FSPEAKKFKW DNKPSEQKLV PSSTVRDISS GLFDKPASVQ
     KKMVPLRFSM MELTRGMDRL KTHQKEQNDQ GPKYRRFRAK INPGENQSAE DELKKEISKD
     MFKEMEIIGQ FNLGFIITKL KSDLFMIDQH ATDEKYNFEM LQQHTVLKGQ RLIVPQNLHL
     TAVSETTLIE NLEIFKKNGF DFLIDEDAPV MERVKLVSLP TSKNWTFGPA DIEELIFMLS
     DSPGVMCRPS RVRQMFASRA CRKSVMIGTA LNTSEMKKLV VHMGEIDQPW NCPHGRPTMR
     HLANLEIISQ D
//