ID A0A3B4BY49_PYGNA Unreviewed; 664 AA.
AC A0A3B4BY49;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Prospero homeobox 2 {ECO:0000313|Ensembl:ENSPNAP00000003486.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000003486.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000003486.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017546321.1; XM_017690832.1.
DR RefSeq; XP_017546322.1; XM_017690833.1.
DR AlphaFoldDB; A0A3B4BY49; -.
DR Ensembl; ENSPNAT00000008647.1; ENSPNAP00000003486.1; ENSPNAG00000009888.1.
DR GeneID; 108423501; -.
DR CTD; 283571; -.
DR GeneTree; ENSGT00940000154790; -.
DR OMA; SPQQRMC; -.
DR OrthoDB; 2877587at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR PANTHER; PTHR12198:SF9; PROX2 PROTEIN; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 510..664
FT /note="Prospero"
FT /evidence="ECO:0000259|PROSITE:PS51818"
FT REGION 83..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 74781 MW; DB31E976E035362F CRC64;
MNLTPPDQSI HKPNDGCLED NKADLMLPCF RRGMYEEPLS SYHSGSLISH LLRKTIHSKR
PALNNAHLYL PPSSVSGAGL VESGSTLAES AQEDRSSMSS KDSLGESSSP GGHASGMSAE
PERPLSEHLQ AKRARVENII RGMAGSPSDR SHGEGDGVEG ETGRYGTEVY KESKRKRKLP
QHQEHSHSTT LTTTSSANIS KDEECHKLRE QLQSMQRLLR QLQEKFLQMY DHGNSENEEK
GEGDFQEDVS EAQLDLSIDS DNKRIGNKER MKADGGYLST ERDQKSLQEM LKCELSRAVS
ESVDMVFRKL SVTLQNQSPQ PQACQSPEYT NVEKRAQQTC APELSDSEDI SKSRLLEFYE
STPVPSPEHQ TEALSLVVRK PTLNQLGSVS QQVKRPYPLH QAPFQFSYSA PLHDSQILEH
LLKYGPHANF GGIPCLPPSL DRSSPDSMDL PWESIAMRSK VSSGHLGQHH RPGALGQVTV
DSLCLPHVKM ECGDLQSMAE RSTFMSLNIQ EGLTPNHLKK AKLMFFYTRY PSSNVLKTFF
PDVKFNRCIT SQLIKWFSNF REFYYIQMEK FARQAIVDGV SDVKDLAVTR DSELFRALNM
HYNKANDFQV PDRFLEVAEI TLHEFYNAIS LNKDTDPSWK KAIYKVICKL DSDVPEEFKS
PSYL
//
