ID A0A3B4BYQ1_PYGNA Unreviewed; 1623 AA.
AC A0A3B4BYQ1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Unconventional myosin-IXb-like {ECO:0000313|Ensembl:ENSPNAP00000004713.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000004713.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000004713.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 42514.ENSPNAP00000004713; -.
DR Ensembl; ENSPNAT00000006550.1; ENSPNAP00000004713.1; ENSPNAG00000011162.1.
DR GeneTree; ENSGT00940000156845; -.
DR OMA; HAMLNKR; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 3.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46184:SF2; UNCONVENTIONAL MYOSIN-IXB; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00063; Myosin_head; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00109; C1; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 15..106
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 134..899
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1286..1334
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1352..1535
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 780..802
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 957..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1026
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 227..234
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1623 AA; 186562 MW; FDD58D2AEA779A4D CRC64;
MSFPESRKSA YLDEATYVLQ IYPRLSLKTA QCCTLNVHKE ATAAWVIQIA AVTLGLDKSK
PYQLVEVRET GGEEWVLQAS DRPVERLLLW PRKVQDQHLQ IHGYYFALQS GVPDGPSQSE
RVLYVRSFLK PQSEDCNDLC SLPVLTEKNI LEALRRRFLK NQIYTYANNI LIAVNPFKFL
PIYNPKYVEM YENHTLGRLN PHVFAIADAA FRAMLNKRLN QCIVISGESG SGKTQSTNFL
IHCLTAFSRK GCTSGVERTI LGAGPVLELQ AFGNAKTAYN NNSSRFGKFI QVNFLEGGVV
RATIEKYLLE KCRLVSRKSC ENYHVFYYLL VGASDEEREE FKLQEPEDYH YLRQQDNPHL
EDQAEIQYEF KRLHQAMEMV GFLPATKKIF SVLSAILYLG NLTYEAKADG EGLTVGPADV
LSTLSDLLKV KKEPLVEALT KRRAMTANDV LILPYTLSEL QAITARDSMA KSLYSSLFDW
IVLRINHALL NKRDMEESVP CLSIGVLDIF GFEDFRTNSF EQFCINYANE QLQHYCNQHI
FRLEQFPHAT DNTLLEKFKQ QHQENLFFVP TPVMEPAFVI LHYAGKVKYQ IKLQDFRAKN
TDHMRPDMVA LLRSSERGYL RQLIGSDPVA VFRWGILRAV VRTVATFKEA GRRWVTEHPQ
SLIDFSFDRS EENPLEVFED IFATFESKEL HAKVLCTIKR LGGEVPQKLR LSTISVRKSR
QFFKSRTNRH KQLIPKNLID SRALKLIVDL NLHNRDTRSL LHLHKKKKPP SISAQFQTSL
VRLLDTLKKA EPFFVRCIRS NAEKREMQFD EDLVLKQLRY TGMLETVRIK RSGYGAKYTF
KQEFTDEFRV LLPKNPSTPQ KDITNLLRRT GLDDSSFQIG KTKVFLKEVD RQKLQETLHR
EVMHRILLLQ RWFRACLTRK HFLMKRKAII TLQQRSWRGY HESTCFRAAS VIQAAWRQSH
RKENESPSPA PTRPGTLDLS SGPKLAQPVQ DDSSNTAPLQ RYSKPSTMKE KVEKWKERRS
EILPPDRSSL KDQQLENQKL KSLSRGISMS LDNLSKFSSS ESDSSPPTKN EKRSRRRLRH
KRRLARPRSS LMLKGMEDAD PDYWSFPLPP LSPSEPFRTK RLTPQDGSVT MARTLAERDA
GRNPTIRISR GTRVQDQFDA FLDRQITDSD ELRHLDEYLG NQMNDLHSQA KVRSETEEIF
LKATTQFRDT IKSMYSVSNP QVSYKGLLQG YKSKVTNLAG QKKKDEVPMV VNLFQSVLDN
FIRAEIKKAS LERASSDPAK PDSPLDHCFS TYQVNIYQSC DLCSSYIWGM EKACMCSCKM
VCHKKCLSKI VLFCSKHIES GKSTAHFGVH VSSLTSNQTP VPVVMEMMLS YVELHGLYTE
GIYRKSGSAC KAKELHQLLE TDPKSECLNN YPIHTVTGLI KCWLRELPEP LMTFSLYNDF
LYAALPEKSE RLRAIYRKVE DLPAPNYNTL ERLIFHLVRV AKEEAHNRMS ANSLAIVFAP
CVLRCPDVSD PLLSMKDLPR TTCLEILIME QTRRYEEKMK EIQQLEHAEA LAIKQLTLQR
KNTSPMDSLG TEVEKTLRER IKSIKLVLPE LDQDASDNET LDTESMISLE CSLDDHFVSS
VSE
//
