ID   A0A3B4BZ20_PYGNA        Unreviewed;       464 AA.
AC   A0A3B4BZ20;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Phosphoinositide-3-kinase regulatory subunit 3 {ECO:0000313|Ensembl:ENSPNAP00000003766.1};
GN   Name=PIK3R3 {ECO:0000313|Ensembl:ENSPNAP00000003766.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000003766.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000003766.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   AlphaFoldDB; A0A3B4BZ20; -.
DR   Ensembl; ENSPNAT00000008151.1; ENSPNAP00000003766.1; ENSPNAG00000010211.1.
DR   GeneTree; ENSGT00940000156259; -.
DR   Proteomes; UP000261440; Unplaced.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 2.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          67..162
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          360..454
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   COILED          176..210
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   464 AA;  54630 MW;  62DA6AF52A72572B CRC64;
     MYNTVWNTEK EDDDWRDVMM PYSTELIFYI EMDQPPALPP KPAKPMTPVN SNGVKEAASS
     SLQEAEWYWG DISREEVNDK LRDMPDGTFL VRDASTKMQG DYTLTLRKGG NNKLIKIYHR
     DGKYGFSEPL TFSSVVELIS HYRHESLAQY NTKLDVKLMY PISRYQQDQL VKEDNIDAVG
     KKLQEYHNQY QEKSKEYDRL YEEYTKTSQE IQMKRTAIEA FNETIKIFEE QCHTQERYSK
     EYIERFRREG NDKEIERIMM NYAKLKSRLG EIHDSKIRLE QDLKTQALDN RETDKKMNSL
     KPDLIQLRKI RDQYLVWLNH KGVRQKRIND WLGIKNENTD DAYFVSEEDE NLPHYDEKSW
     FVGDLNRTQA EDLLLGKPDG AFLIRESSKK GCYACSVVVD GEVKHCVIYS TPRGYGFAEP
     YNLYSTLKDL VLHYHQTSLV QHNDSLNVRL AYPVYAQMPS GPRR
//