ID A0A3B4BZ61_PYGNA Unreviewed; 1403 AA.
AC A0A3B4BZ61;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Chromatin-remodeling ATPase INO80 {ECO:0000256|ARBA:ARBA00019805, ECO:0000256|RuleBase:RU368001};
DE EC=3.6.4.- {ECO:0000256|RuleBase:RU368001};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000003806.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000003806.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: ATPase component of the INO80 complex which remodels
CC chromatin by shifting nucleosomes and is involved in DNA repair.
CC {ECO:0000256|RuleBase:RU368001}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|RuleBase:RU368001};
CC -!- SUBUNIT: Component of the INO80 chromatin-remodeling complex.
CC {ECO:0000256|RuleBase:RU368001}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU368001}.
CC -!- DOMAIN: The DBINO region is involved in binding to DNA.
CC {ECO:0000256|RuleBase:RU368001}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025, ECO:0000256|RuleBase:RU368001}.
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DR Ensembl; ENSPNAT00000008091.1; ENSPNAP00000003806.1; ENSPNAG00000010386.1.
DR GeneTree; ENSGT00900000141110; -.
DR OMA; DHRIMRS; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0031011; C:Ino80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd18002; DEXQc_INO80; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR020838; DBINO.
DR InterPro; IPR031047; DEXQc_INO80.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45685:SF2; CHROMATIN-REMODELING ATPASE INO80; 1.
DR PANTHER; PTHR45685; HELICASE SRCAP-RELATED; 1.
DR Pfam; PF13892; DBINO; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51413; DBINO; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU368001};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU368001};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU368001};
KW DNA-binding {ECO:0000256|RuleBase:RU368001};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368001};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..331
FT /note="DBINO"
FT /evidence="ECO:0000259|PROSITE:PS51413"
FT DOMAIN 455..626
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1018..1173
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1193..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 287..317
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1271..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 160282 MW; 741E4A665BF39BC2 CRC64;
MASEQDGMDS ACSKLAKPLH LQHLERSLRL DAFLLIQFFG NLFIYFGYIA QYITISPTEH
KADKANLYNF SKLRKSRKWL KGILLSDDTT DSDTDSDDSD FSMTREELHD MLRLHKFTRL
HQSKFHTDRE LQQYQYYSTG LLSTQDPFYE QQRHLLGPCL MLFYLSMEGR PYVTKIFAKF
SHDAPPPITK KKHLTLEQLN ARRRKVWLTI AKKENPKAFK QKASAKNFVL TNAKKLAHQC
MREVRRAAIQ AQKNCKETLP RARRLTKEML LYWKKYEKVE KEHRKRAEKE ALEQRKLDEE
MREAKRQQRK LNFLITQTEL YAHFMGGKHN GGDSSQEEIL RKLDENTAQR QIDIGGGVMV
NMGQEDYDSE YYKSQALRNA KEAYHIHQAR TRQFDEEAKD SRCASLHVAS VSGSGFGESY
SLSNPSIQAG EDIPQPTIFN GKLKGYQLKG MNWLANLYEQ GINGILADEM GLGKTVQSIA
LLAHLAERDN IWGPFLIISP ASTLNNWHQE FTRFVPKFKV LPYWGNPHDR KVIRKFWSQK
TLYTQNAPFH VVITSYQLVV QDVKYFQRVK WQYMVLDEAQ ALKSSTSVRW KILLQFQCRN
RLLLTGTPIQ NTMAELWALL HFIMPTLFDS HEEFNEWFSK DIESHAENKS AIDENQLSRL
HMILKPFMLR RIKKDVENEL SDKIEILTYC QLTSRQRLLY QALKNKISIE DLLQSSMGTA
QQAHSTTSSL MNLVMQFRKV CNHPDLFERQ ETRSPFHMSL KPFIMSKFLF RQGLLNTCSQ
GRAKLLQVLL SPFSPQHIQQ SLFHRKSDDE GSCFSFLRFI DVSPAEMSNQ MLQGTLTRWL
ALYLSFKSAH RLHHQRLWAE AEVCERKAEW SSVGHCLSNR DFVLWPDRPT SFPNTHSSTV
LRVSHSGYHG ATRSPHSHYT DQPPKFILTV TAVPIERCCP DRSAEYEWRQ VRDGGSLAAK
QCFLYGSPEL AYAWAARSHS FHPESPGGMM ALQPRHGWSF IRIPDKESLI TDSGKLHTLD
LLLTRLKSQG HRVLIYSQMT RMIDLLEEYM VYRKHTYMRL DGSSKISERR DMVADFQSRT
DIFVFLLSTR AGGLGINLTA ADTVIFYDSD WNPTVDQQAM DRAHRLGQTK QVTVYRLICK
GTIEERILQR AKEKSEIQRM VISGGNFKPD TLKPKEVVSL LLDDEELEKK LRLRQEEKRQ
QEESSKVKDR KRKREKYAEK RKKDDDVEAK KKKEGVNLVI PYAPSADNSN LSADGEDSFI
SVDMDSAMPS PFSEISLSSE LQPGSLPADE SSSDMLVIVD EPVSSAPQSR ATNSPASGTG
SVSDNMNGVS SQDTSSPGRG RSGRSRGRPK GSGGAGKCSS RKGRGRKSTA GSAAAIAGAM
AGAAAASAAA YAAYGYSVSK GEF
//
