ID A0A3B4BZ66_PYGNA Unreviewed; 1574 AA.
AC A0A3B4BZ66;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Complement C3-like {ECO:0000313|Ensembl:ENSPNAP00000003811.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000003811.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000003811.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR STRING; 42514.ENSPNAP00000003811; -.
DR Ensembl; ENSPNAT00000008095.1; ENSPNAP00000003811.1; ENSPNAG00000010840.1.
DR GeneTree; ENSGT00940000154063; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR CDD; cd03583; NTR_complement_C3; 1.
DR Gene3D; 1.20.50.70; -; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048848; C3_CUB2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035815; NTR_complement_C3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21308; C3_CUB2; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1574
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017393675"
FT DOMAIN 653..688
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1430..1572
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1574 AA; 176739 MW; 56A45B5E80351238 CRC64;
MGQVDLLWIT AALLSSPLLT LCDPLNILSA PNMLRVGSSE NVFVETQDYA EGTLNVRVAV
KNYPQKTVEL ESKSVVLDAG NNYQALVAIK IPENKDIFSD DPLEKEYVYL QAHFPSGVLE
KVVLVSFQSG YIFIQTDKSI YTPSSTVKYR VFAMTPDLQP LDFSAVSVEI IVTRYKSTPQ
KNFTAEFEVK EYVLPTYEVT LNPSRSFFYI DDDRFQVDII AKYLFGNKVE GSAFVVFGKI
HHKSTFNKFE CLCFLNLLNA FSFIQPDGEG RATLTKEMIQ KTFVDIKQLV GSSLYISVSV
LTNVGSEMVE AQRRGIPIVS SPYTIDFKRT PKFFKPGMPF DVTVYVANPD QTPAENVDVI
VNPGGGQGRT KANGIAKVTV NTQTGAKSLQ INVTTNDPAI SNNRQDEKQM TAEAYATKGG
SINYLHIGIG AEELKVGDNM KINLNFIKSS GVQNQDFTYL ILSKGQIIQA KRFKRQGQTL
VTLSHLVTKD MLPSFRVVAY YHVGESEVVA DSVWVDVKDT CMGTLRLDVK DPRRSYDPGE
KFSLKITGDP GAKVGLVAVD KGVFVLNKNR LTQEKIWDII EKHDTGCTAG SGKDSLGVFY
DAGLLFVSDK AGSTSSRTTI ACPTPPKRKR RAEALLQIIQ TLTGKYTGYL KKCCTDGLKP
NKLGYTCERR ATFITDDAEC VQAFLTCCKE RQTRKLMIVE EEMVLARKED DFDIITSRTQ
FPETWLWEDM VLPSCQDNLF LKDSITTWQI LAISLSQTHG ICVADPYEMV VKKDFFLDLK
LPYSAVRNEQ LEIKAILHNF SNNKYKVRVD FIETEHVCSA ASKRGKYRTT VDVDAQSSRS
IPYTIIPMEL ENHWIEVKAS VYGSTIGDGI KKALKVVVMQ VFHLRSDIPE RQIPGSHANT
YITLTGQDLS QTIEQAISGN FMGRLIVQPS GSAEHNMIYM TLPVIATHYL DTTKQWEEVG
FDRRSEAVKH IQTGYEQELT YRKDDGSYAA WTNKPSSTWL TAYVAKVFAM ASGLITIEEN
VLCSAIKWLV LKTQMPDGTF KESAPVIHTE MVGDVQGKDA DASLTAFILI AMQEGSERCA
KAVPRLSESI KKATEYLARR LTTLRNPYAV AMTSYAMANA GKFNKDLLMK YSSGDGAFWP
VPRGHHFTVE ATAYALLALV KAKEFDAAGK AVKWLNTQTS PYGSTGTTQA TIMVFQSVAE
YYKQVRRFHR GDLDVELSVS GRSQRTNWNI RKETSSLTRS DKVNLKQEFN VTAKGNGVAS
LKVITYYYAR PTEKEGDCKD FNLTVKMEKQ RDGKVHHDPN VYNSETRDAT MSILDIGLLT
GFVVDEKDLK DLTTGTDRYI QKFEMDKQLS ERGSLILYLD KVSHRMMDRI AFGMHKNSEV
AMLQPAGITV YEYSSPDKRC TKFYHPMKKD GALHRLCNTE GLCRCAEENC SIQKKQKIDD
KDRQKKACEP GLDYVYKVKV VKTDLSPYTD YYTMKIEQVL KEGTDAGVEG QERNFMGHAN
CRESFGIEKD KTYLIMGRSV DLPKIDGRLQ YILGEQTWIE YWPTNGEGQT QTYREKYLGI
TGLAQHLLTI GCTT
//
