ID A0A3B4C0B4_PYGNA Unreviewed; 1297 AA.
AC A0A3B4C0B4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Caskin-2-like {ECO:0000313|Ensembl:ENSPNAP00000004094.1};
GN Name=CASKIN2 {ECO:0000313|Ensembl:ENSPNAP00000004094.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000004094.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000004094.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_017558015.1; XM_017702526.1.
DR Ensembl; ENSPNAT00000007599.1; ENSPNAP00000004094.1; ENSPNAG00000010599.1.
DR GeneID; 108430175; -.
DR CTD; 57513; -.
DR GeneTree; ENSGT00940000158256; -.
DR OrthoDB; 25046at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 27..59
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 60..92
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 93..125
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 161..193
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 193..225
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 254..320
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 510..573
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 579..643
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 324..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..801
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1297 AA; 140338 MW; 401859AA8CB8FAFA CRC64;
MGQVAVCARS ELLGSTKKLN VNYQDADGFS ALHHAALTGT TDLLSLLLEA QAMVDIKDSN
GMRPLHYAAW QGKADSVLML LRAGASVNGA SQDGQIPLHL AAQYGHYEVS EMLLQHQSNP
CMVNKAKKTP LDLACEFGRL KVAQLLLSSN MVVALLEGNG RDNTPLHLAA RNGHKDIIRL
LLKAGIDINR TTKAGTSLHE AALYGKTEVV RLLLDAGIDV NIRNTYNQTA LDIVNQFTTS
HASKDIKQLL REASGALQVR ALKDYWNLHD PTALNIRAGD LIMVLEQHID GRWKGHIHDS
QRGTDRVGYF PPSIVEVINR RGTLSRQASL PSQRHHTLAR VPSPRSPHPA PHTDDSYTLY
ASTHPALPRQ NGLDQHPGSP PDSPSALCIP ASPKEPEDIW VLRTSQTGDR NSVGSAGSVG
SSRSAGSGQS TEGNFTHNVQ YHSSTITQDI NKMSPSAGES VEQHKLTPDL SKPEPAGAPG
RRQALSSSRA GEHGLSPYVH IRPEQLLEGR DAEAIYQWLS EFQLEQYTAN FLTAGYDVPT
ISRMTPEDLT AIGITKPGHR KKISMEISHL HIPEWLPDYI PSDIGEWLGT IGLSQYQKRL
AENGYDSVSI VRDITWEDLQ EIGINKLGHQ KKMMLAVKRL CDVQKAQKNQ VEGQGMLQRT
APPTLELVAI EPPDNADGPS SPLSPKMLTF QDSELSAELQ SAMTQSGYAG CQVDLSAAVS
ETAVSVSQES TRSWGSGRSQ ERPLASVTPH SRSDENLSPG NSPCKDRYAI SECQVIPTKM
LPALPLQQQH HPPPASPSST QTPPITPSKA SRFIYPAVQS KPRPGVSTAL PQLIAPHGSP
ITRGFSYLQP QNISSDQART RPTRPAQPSG EIHRPKKRSQ SLSRYALSDG EAEEEEAPAP
SANLASYATL TRKPGRSHPP AAASEHHVGR SHSFAIRARR KGPPPPPPKR MSSAPSTVNS
SGVDTDSAGS VRSIAARLEG SGGSPTKTHS SPTFKPVSNA TPVMTTGSRR RTTGEPFSNE
PDQELCGVKS VEQDKKLQAK QEHVVSVSPQ GTLCESIPFA EEGKVTIKQR QKIALVKTDT
EVNFESQKPT QPPKSSLESP EFNLTESDTV KRRHKPREKE PLTASQNTQS VPGAEKISPC
LQNGGPPRNL LKQNVCPKPV SPQKPPTPCK PTRHSAAAPL VDGSPPGMCV RMGQNPAFTL
SSPSGSVAVC PPIRGPLDQN SRVQPQARGQ GPDELVHKRL EQTSTSLEAA LKVVEKKLAQ
EDQTDSGIYT VKSAGNILDD IGNMFDDLAD QLDAMLD
//
