ID A0A3B4C338_PYGNA Unreviewed; 682 AA.
AC A0A3B4C338;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN Name=MPEG1 {ECO:0000313|Ensembl:ENSPNAP00000005004.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000005004.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000005004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR RefSeq; XP_017570284.1; XM_017714795.1.
DR AlphaFoldDB; A0A3B4C338; -.
DR Ensembl; ENSPNAT00000006063.1; ENSPNAP00000005004.1; ENSPNAG00000011320.1.
DR GeneID; 108437601; -.
DR GeneTree; ENSGT00390000008048; -.
DR OMA; YTAKLQP; -.
DR OrthoDB; 4221421at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..682
FT /note="Macrophage-expressed gene 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017204611"
FT DOMAIN 29..344
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
SQ SEQUENCE 682 AA; 75209 MW; 2003AA9E0037E7B2 CRC64;
MGSICFSLLS IFALISTCDL HPLSHPDNGL RECRKNLSSP ALEVLPGGGW DNLRNLDMGR
VMNMSYSQCQ TTEDGVYLIP DEVFVIPQKV SGVEMNSEII SSWLEQKSTT SSSINADVSY
TSVLNGKFST ENERMKTHQV KDTSVTSRVQ VRNHLYTVKV FPGFTLDSRF ARQAEEIADA
IENNQTRQAN YLSEKMILDY GTHVITSVDA GATLVGEDYL KSSYVSDAES SQSSVSASAG
ANFFNKVKFD IGGKESQETS ETLSYQGNIT YSITLSHGGA LFFPGITLQK WQESTLNNLV
AIDRSGLPLH YFLNPSVFPD LPRPTVNKVA LFVSQAIERY YKINTRPGCV KPDSKNFNFQ
ANVDDNSCEG PSTNLNFGGV YQQCTSLTSD GDVICQELAE KNPATGSYSC QQLYTATLLR
SETQERSYDK YECNKHCVSC GFLWLFTCCD EVCGNVYYAQ SARIDTYWCS TNVVAPEFSG
YLFGGLYGPS LQNPLTKSKS CPPNFFSQKV LSNSFMICLS NDYETATRFS VPFGGFFSCQ
STNPLAGSQS RCPPQFSQHL AAISDGCQIL YCVQSGVFTG GELLPIHLPP FIRPPVMGMI
ATNTVAVMTD GTRTWVRVKD TKMWRAAKPE DINKISQIFE DSPQSAGKKA GLAIAVVFVA
IMAIVADKLM KTGRELRNRK TQ
//
