ID A0A3B4C3A5_PYGNA Unreviewed; 406 AA.
AC A0A3B4C3A5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Small RNA binding exonuclease protection factor La {ECO:0000313|Ensembl:ENSPNAP00000005500.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000005500.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000005500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017571033.1; XM_017715544.1.
DR RefSeq; XP_017571034.1; XM_017715545.1.
DR RefSeq; XP_017571035.1; XM_017715546.1.
DR STRING; 42514.ENSPNAP00000005500; -.
DR Ensembl; ENSPNAT00000005184.1; ENSPNAP00000005500.1; ENSPNAG00000011708.1.
DR Ensembl; ENSPNAT00000005201.1; ENSPNAP00000026402.1; ENSPNAG00000011708.1.
DR GeneID; 108438040; -.
DR CTD; 6741; -.
DR GeneTree; ENSGT00830000128380; -.
DR OMA; QFERSIY; -.
DR OrthoDB; 5477115at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd08028; LARP_3; 1.
DR CDD; cd12291; RRM1_La; 1.
DR CDD; cd12541; RRM2_La; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR014886; La_xRRM.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792:SF172; LUPUS LA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR22792; LUPUS LA PROTEIN-RELATED; 1.
DR Pfam; PF05383; La; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF08777; RRM_3; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS51939; XRRM; 1.
PE 4: Predicted;
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00332}.
FT DOMAIN 4..96
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50961"
FT DOMAIN 108..185
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 225..350
FT /note="XRRM"
FT /evidence="ECO:0000259|PROSITE:PS51939"
FT REGION 197..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 45991 MW; E0518F6EC70C542A CRC64;
MAEEQEVSPL EKKVAEQIEY YFGDHNLPRD RFLKEQMQLD DGWIALETML KFNRLKSLTS
DAAVIVRSLQ KSKTGLLEIS EDQTKIRRCP SKPLPEHNEE YRDALKHKSI YMKGFPLDTT
LDEIKDWLAD KGNVENIQMR KGLQKTFKGS IFAVLESEDA AKAFVARDDV KQFKGNDMIV
LMKDDYFAKK ADSRKQSRAD AKAKARSEKE EKQKQAEEEE MKSLDEQRGC LLKFSGDLGQ
TSREDFHEIF SEHAQIKWID FTRGAKEGTI LFRSNAKEAL QKAQEAAGGA ELKVKDKAVQ
WEVLEGDVEM ETLKKIIESQ QESLNKRKGG KGGHRGRGRG RGGRRDRGGR EQVQFRGKRT
KFDSDDEDGG RDGDADITGP KKRALESNGK DAEAPAPKQA KEESGS
//
