ID A0A3B4C3I2_PYGNA Unreviewed; 1241 AA.
AC A0A3B4C3I2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Protocadherin 7 {ECO:0000313|Ensembl:ENSPNAP00000005154.1};
GN Name=PCDH7 {ECO:0000313|Ensembl:ENSPNAP00000005154.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000005154.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000005154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017555117.1; XM_017699628.1.
DR AlphaFoldDB; A0A3B4C3I2; -.
DR STRING; 42514.ENSPNAP00000005154; -.
DR Ensembl; ENSPNAT00000005780.1; ENSPNAP00000005154.1; ENSPNAG00000011447.1.
DR GeneID; 108428560; -.
DR CTD; 555504; -.
DR GeneTree; ENSGT00940000157221; -.
DR OrthoDB; 5353710at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR013585; Protocadherin.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF253; PROTOCADHERIN-7; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1241
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017457594"
FT TRANSMEM 848..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..139
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 140..278
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 279..385
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 402..505
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 506..609
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 610..712
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 723..832
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 879..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 135613 MW; DF0254D7282D181F CRC64;
MRTTGAVDCM CYCWLLLQLL SQPAAAKQVL RYRLAEEGPP DVRVGNVAAD LGIVAGSGEV
TFTLESGSDY FKIDNITGDL STNERRIDRE KLQQCQMIFD ENECFIDFEV SVIGPAQSWV
DLFEGKVIIL DINDNTPSFP SPVLTLSVEE NRPIGTLYLL PTATDRDFGR NGIERYELIQ
DGAESSVRRL GSASADVHAA KRRFDDAQSR SSVFELQVAD TTDGEKQPQL IIKGALDREQ
RDSYELTLRV RDGGDPPRSS QAILRVMITD VNDNSPRFEK SVYEADLPEN SSPGAPILQL
KAVDADVGVN GQIEYVFGAA TESVRRLLRL DESTGWLSVL HRIDREEVSQ LRFTVMARDR
GQPPKTDKAT MIINIKDEND NVPNIDIRKI GRIFLRDGVA NVAEDVVVDT PIALVQVSDR
DKGPNGVVTC TVVGDVPFQL KPASEIEGDM NKKKYFLHTS APLDYEAVQE YNVVIVAVDS
GSPSLSSNNS LIVKVGDMND NPPIFTKSTV EVSFPENNAP GERVATVVAL DADSGKNAEI
SYSLDSSVNG IFSIDPDSGD IRVNTILDRE QTERYEFKVI AKDKGVPVLQ GSATVVVLVA
DKNDNEPKFM QDVFTFYVKE NLQPNSPVGM VTVMDADKGQ NAEMSLYIEE EEDIFSIENN
TGTIFSTVAF DREQKTTYSF RVKAVDGGDP PRSATATVSL FVMDENDNPP TVTFPINSSY
TLLPPSSNIR TVVRTVIATD TDTGVNADLS YSIIGGNPFK LFEIDPATGV ISLVSKLEQK
HFGLHRLVVQ VNDSGVPSQS TTTLVHVYVN ETLSNSTIVD AQIAKSLGTP LNADIAGDPN
YDLGKQRLSI AIGVVSGIMT VILIILVVVM ARYCRPKNKN GYEAGKKDHE DFFTPQQHDK
SKKPKKDKNK KKSKQPLYSS IVTVEASKPN GQRYDGVNEK LSDSPGMGRY RSVNGGPGSP
DLARHYKSSS PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGTGDNISIG SDHCSEYSSQ
TINKYNKQPF RRVTFSVVSQ PQDPHQGSLQ SCYDSGLDES ETPSSKSSTG PRLGALPLPE
DAYERTTPDG SVGEAEHMEN DSRPLPDVAM TGKCTRECDE YGHSDACWMP VRTSPERRPK
ATPPKLSTFM TSPGGSVAEQ PGSQETLAVA NGDPSHLLGD RNRNLLNKKM ASSSSSYDAF
SSAGFSSVEE TSRPTEEIPL APTGEYKPTQ CGTLTRREVY L
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