ID A0A3B4C3K4_PYGNA Unreviewed; 1961 AA.
AC A0A3B4C3K4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cytoskeleton associated protein 5 {ECO:0000313|Ensembl:ENSPNAP00000005610.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000005610.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000005610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR STRING; 42514.ENSPNAP00000005610; -.
DR Ensembl; ENSPNAT00000005001.1; ENSPNAP00000005610.1; ENSPNAG00000001967.1.
DR GeneTree; ENSGT00390000014757; -.
DR OMA; NWKERKE; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 5.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 268..505
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 439..477
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 558..788
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 820..1052
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1128..1371
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 242..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1885..1961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1836..1864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1945..1961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1961 AA; 218870 MW; 4BFB8453B2AEA407 CRC64;
MGDDSEWMKL PVDQKCEHKV WKARLNGYEE ALKLFQRIGD EKSPEWGKYL GLIKKFVTDS
NAVAQLKGLE AALVFIENAH VAGKTTGEVV SGVVSKVFNQ PKARAKELGT DICLMYIEIE
KAEIVQDELI KGLDNKNPKI VVACIETLRK ALSEFGSKII TLKPVVKVLP KLFESREKAV
RDEAKLLAVE IYKWIRDALR TPLQNINSVQ LKELEEEWVK LPAGAPKQSR FLRSQQDLKA
KFEQQQATGG DEGDDDDGEA DTHVDPYELL EAVEILSKIP KDFYEKIEAK KWQERKEALE
AIETLSKNPK LESGDYGDLV RALKKVVGKD ANVMLVTLAA KCLAGLAAGL RKKFGTYAGH
VVPTVLEKFK EKKPQVVQAL QEAIDAVFLT TTLQNISEDV LAVMDNKNPS IKQQASLFLA
RSFRHCTPAT LPKSVLKPLC AAFLKQVNDS APEVRDAAFE ALGTAMKVVG EKAVNPFLAD
LDKLKLDKIK ECADKVELVG GKKGGGGGGE KKEKPAAKAP PVEEPPPKAA VGAPKKAHLA
KLCLLLFLIN VLFVCSTQLE VCEEKSAAVL PASCMQLLDS ANWKERLASM EEFQRAVEQM
DRSQMPCQAL VRMLAKKPGW KETNFQVMQM KLHIVGLIAQ KGSFSKTSAL VVLDGLVDKI
GDIKCGSNAK EALTAIGEAC SLPWTAEQVV SLAFAQKNPK NQAETLNWLA NAMKEFGFAG
INVKAFINNV KTALGATNPA VRTAAITLLG VMYLYMGAPL RMFFEDEKPA LLSQIDAEFE
KMQGQSPPAP MRGMTKKGAE EEGEDADEEE VDGGAGDIMD LLPRTDISDK ITSDMVEKIG
DKNWKIRKEG LDEVAAVISE AKFIQSNIGE LPMALKGRLT DSNKLLVQQT LSILQQIATA
MGPSLKQHVR NLGFPIITVL GDSKPNIRTT AMTTLNAWVE QTGLKEWLEG EDLSEELKRE
NPFLRQEVLG WLAERLPTMR SVPADLMLCI PNLYACLEDR NGDVRKKAQD ALPTFMMHLS
YDKMNKATSK LKPASKDQVV AMLEKARAVM PAKPAAPAKA APSKPAQSAP AAKPGVVGKK
APVKPTPKDD EDKSGPIFIL VPNSKEQRMK EEKALKILKW NFITPRDEYV EQLKTQMASC
LAKWLQDELF HYDFQRHVKA VNAMIEHMEA ESEAVIGCLD LILKWFTLRF FDTNTSVLMK
AMEFLKLLFT MLSRENYHLS EYEASSFIPY LILKVGANVF QKFITSIIVY VRAILTMLCN
VYSACKMFPF LMEGTKSKNS KQRSECLEEL GCLIENYGMN VCQPTPAKAL KDIAVHIGDR
DTTVRNAALN TVVAAYNVCG DQVFKLIGNL SEKDLSMLEE RIKRSAKKTP VVSAKQERAP
REHPANPNAT FLRKPAQEEV PNKLNQARSQ NAHSEHTAPS IPKEFQLDLD MIENDHTRVS
EFPDLVQHKL DELLEPVTIP EPKIRSVSPH FDDLHNSTAS TINFVISQVA SGDINTSIQA
LAQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYNTHM ADDRLDKKDI FKLYSCIIGN
MLSLFSMESL AREASMGVLK DLMHGLITLM LDSRVEDIED GQQLIRSVNL LVVRVLEKSD
QTNILSALLV LLQDSLITTA GSPMFSELVM KCLWRMIRFL PETINSINLD RILLDVHNFM
KVFPKEKLKQ LKSDVPHRTL KTLLHTLCKL TGAKILDHLS MIENRNESEL EAHLRRVVKH
SGNLSGFKSD QNTEKGALRS DDKVIKAKVS DILSEIFKKI GSKENTKEGL TELYEYKQKY
SDADLEPFLK NTSQFFQSYV ERGLRMIESE REGKSRIQPS TVIPQHSTES YTPSHSSMSV
NSNGEDLKPA VYYERLKILR QRHGLENAKQ DDERPPFSSL SKPPLASSTD MLHSKLSQLK
ESRESHFQQD SRSHSPGRAS SPAANLDDLK KRLERIKSNR Q
//
