ID A0A3B4C5S3_PYGNA Unreviewed; 1713 AA.
AC A0A3B4C5S3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSPNAP00000006435.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000006435.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000006435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPNAT00000003591.1; ENSPNAP00000006435.1; ENSPNAG00000012648.1.
DR GeneTree; ENSGT00940000156023; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1016..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1210..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1250..1268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1274..1298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1310..1332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1397..1421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..330
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 383..603
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 886..1162
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1221..1431
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 797..826
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1585..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1713 AA; 197872 MW; 9A41129ABB944001 CRC64;
MLKRKQSSRV EAQPMTDFGP DETLTDSTDI LWINKPWVHS LLRACAIISV ISVCMNTPKT
FEHYPPLQYV TFTLDTMLMF LYTAEMIAKM HIRGIIKGDN SYVKDRWCMF DGFMVVFLWV
SLVLQVFEIA EIVDQMSPWG MLRIPRALIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
VSIFLLFFLL LYGILGVQMF GTFNYHCVTN ETQEHNVTWN SLAIPDTHCS PNGEGYQCPM
GFKCVDLEAH GLSRQELGYS GFNELGTSIF TVYEAASQEG WVFIMYRAID SFPRWRSYFY
FITLIFFLAW LVKNVFIAVI IETFAEIRVQ FQQMWGSRSS TTSTATTQMF HEDASGGWQL
VAVDVNKPHG RAPACLQKLM RSSVFHMFIL SMVAVDVIVA SSNYYKGKNH KKDYDEFYLA
EVAFTVLFDL EALLKIWCLG FTGYISSSLH KFESLLVVGT TLHIYPDLYH SQVTYFQVLR
VVRLIKISPA LEDFVYKIFG PGKKLGSLVV FTASLLIVMS AISLQMFCFV EDLDRFTTFP
RAFMSMFQIL TQEGWVDVMD QTLVAVGHMW APVVAIYFIL YHLFATLILL SLFVAVILDN
LELDEDLKKL KQLKQSEANA DTKEKLPLRL RIFEKFPNRP QMVKISKLPS DFTVPRIRES
FMKQFIDRQQ QDPSCLFRRL PSASSSSCDH SKRSAIEDNK YIDQKLRRSI FSIRARNLLE
KETTVNKILR ACTRQRMLSG SFEGQPTKER SILSVQHHIR QERRSLRHGS TSQRISRGKS
LETLTQDHSS TVRYRNAQRE DSEIKMIQEK KEQAEMKRKV QEEELRENHP YFDKPLFIVG
REHRFRNFCR MIVRARFNAS KTDPITGAVK ITKYHQLYDL LGLVTYLDWV MIVVTICSCI
SMMFESPFTR VMHVPTLQIA EYVFVIFMSI ELNLKIMADG LFFTPTAVIR DFGGVMDIFI
YLVSLIFLCW LPTDVPPESG AQLLMMLRCL RPLRIFKLVP QMRKVVREVL KGFKEIFLVS
ILLLTLMLVF ASFGVQLFAG KLAKCNDPHI TREDDCHGIF RINVSISKNL NLKLRPGEKK
PGFWVPRVWA NPRNFNFDNV GNAMLALFEV LSLKGWVEVR DVIIHRVDPT HGIYIHVFVF
LGCMIGLTLF VGVVIANFNE NKGTALLTVD QRRWEDLKSR LKIAQPLHLP PRPENGGFRA
KMYDITQHPF FKRGIAVLVL AQSVLLSVKV TMKLIAMSPA GYWQSRRNRY DLLVTSLGVI
WIILHFALQN AYTYMMGTCV IVLRFFTICG KHVTLKMLLL TVVVSMYKSF FIIVGMFLLL
LCYAFAGVVL FGTVKYGENI NRHANFSTAG KAITVLFRIV TGEDWNKIMH DCMVQPPFCT
PDKHRYWETD CGNYAGALIY FCSFYVIIAY IMLNLLVAII VENFSLFYST EEDQLLSYND
LRHFQIIWNM VDDKREGVIP TSRVKFLLRL LRGRLEVDLD KDKLLFKHMC YEMERLHNGG
DVTFHDVLSM LSYRSVDIRK SLQLEELLAR EQLEYTIEEE VAKQTIRMWL KKCLKRIRAK
QQQSCSIILS LRESQQQDLR RLLNPPSIET TVPSDDANAN NQDNPTQPEN SGLQTLLSPT
LSDRSGFRQD SGDRPQRKLG QWRLPTGQIS HKNTHRSFSS SNEYFGGRTS VKSMVCKMNP
VSDEASSGSE VKKWWTRQLT VESDESGDDL IDI
//
