ID A0A3B4C5V6_PYGNA Unreviewed; 1039 AA.
AC A0A3B4C5V6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Integrin alpha-3-like {ECO:0000313|Ensembl:ENSPNAP00000007257.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000007257.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000007257.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3B4C5V6; -.
DR Ensembl; ENSPNAT00000002121.1; ENSPNAP00000007257.1; ENSPNAG00000013131.1.
DR GeneTree; ENSGT00940000157746; -.
DR OMA; RYNHTGA; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 22..1039
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017106257"
FT REPEAT 27..92
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 286..347
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 348..401
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 405..467
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 452..601
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 602..751
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 767..968
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1039 AA; 115730 MW; 40CF369A3C06E90C CRC64;
MAPRALHLCL LVFYAVQPGC GFNIDVRFPV VKQGKTQGSF FGFSVAQHKQ TEKAEKYLLL
AGAPRERASS KLRVNETGAI YSCPITTDVT DCTRVELITS TDSSEMIEGM WLGVTVASQR
EQPGGRVLAC GHRYVKIVRG GTEEQRRMVG KCFVRGNDLT FDPNDDWQTH TYEVCNPNFD
MELEGMCNMG ISAGMTESDV YIGSPGSYLW QGNVHITWRD TKPENSWDYN VKDFEPKDTR
NSYLGYSVTE HKKLLDRQEY TVVTGAPRDE SRGSVTLATK GQSNIEVRQT ILGEQVGSYF
GSSIAVTDLN NDDWNDLIVG APFYFDRYKE QGGAVYVFMN ENGSFENKIV LNGVKDSAFG
LAVAAIGDVN QDGFQDFAVG APFHDSGKVY VWMGSKEGIT NAYSQVIEGK SVGSGGFHTF
GYSLSGGMDM DGNKYPDILV GSLDDRIALL RARPVIHLSR NFTVEPKIVD PNQCKDACVT
VKMCYAYTLS NGNLDFKNDI SVKYTIEADR AQRNPRVQFV DTKLNTYTGV LAFSSPTCQE
FKLSVNEQVK NKLEPVVFLL NVSLHEPEVK AQQVLQNLDA FPVLSSKQGV TEKTEINFRK
ECGSDNKCRS NLQVKAVFVN EHQELFPSDG GSQTIEYNNN IKKIMLLVEV TNLPEQGREA
EDAHQAALNI TIPLALKYSG WRTQDPDIVC RPNTTVICEL GNPFKSNKKT TFHIIFETFI
TLYTDQIETQ LQLSTLSEQS DLYPVSIILN VENKILTSFS VEKPVLNTFF SGKVVGESAM
NTTSDVGSPV EFVFKVSVVG EPLGELGTLV IDFEWPYEVM NGKWLLYLTE ILIDGASKPS
CIPAGRVVNP LNLILSEKGP KRNKRDADIG LLHTDATRTL LTPHKESHLL ECSKQTARCV
TFSCPLKNIS TKAAVIVRAR VWNSTMVEDY AEAFRVTVKG HVTLRLLTDK PAIKMDSESR
EFVVNIDPVP GEETQYSAPL WIYIVAGVAG ILLLGIITLV LWKCGFFKRA SRREMYEAKA
QKAEMRIQPS ETEKLTEDY
//
