ID A0A3B4C6E3_PYGNA Unreviewed; 378 AA.
AC A0A3B4C6E3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Vacuolar protein sorting-associated protein 72 homolog {ECO:0000256|ARBA:ARBA00020000};
DE AltName: Full=Transcription factor-like 1 {ECO:0000256|ARBA:ARBA00032814};
GN Name=VPS72 {ECO:0000313|Ensembl:ENSPNAP00000006129.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000006129.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000006129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Deposition-and-exchange histone chaperone specific for H2AZ1,
CC specifically chaperones H2AZ1 and deposits it into nucleosomes. As
CC component of the SRCAP complex, mediates the ATP-dependent exchange of
CC histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC {ECO:0000256|ARBA:ARBA00002050}.
CC -!- SIMILARITY: Belongs to the VPS72/YL1 family.
CC {ECO:0000256|ARBA:ARBA00006832}.
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DR RefSeq; XP_017577188.1; XM_017721699.1.
DR AlphaFoldDB; A0A3B4C6E3; -.
DR STRING; 42514.ENSPNAP00000006129; -.
DR Ensembl; ENSPNAT00000004093.1; ENSPNAP00000006129.1; ENSPNAG00000012209.1.
DR GeneTree; ENSGT00390000017503; -.
DR OMA; YRNTYGG; -.
DR OrthoDB; 12606at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140849; F:ATP-dependent H2AZ histone chaperone activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR008895; Vps72/YL1.
DR InterPro; IPR013272; Vps72/YL1_C.
DR InterPro; IPR046757; YL1_N.
DR PANTHER; PTHR13275:SF4; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG; 1.
DR PANTHER; PTHR13275; YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1; 1.
DR Pfam; PF05764; YL1; 1.
DR Pfam; PF08265; YL1_C; 1.
DR SMART; SM00993; YL1_C; 1.
PE 3: Inferred from homology;
FT DOMAIN 310..339
FT /note="Vps72/YL1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00993"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..72
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 42523 MW; B1BFAFEA41DAAAE0 CRC64;
MSLAFCRAPR KNAGSRMSKL LDAEEEDEFY KTTYGGFNDE SGDDEYKGDL SDTEDEVDSD
FDIDEGEEPD SEQEEDGPRR KSRVVTKAYK EPIKAVKPKP KPKKLSELPR RVDKIKTEKH
KTLELQDDIN RKSVRQSTTE HTRLTYLRLQ ERQVAPRRKK GTRHERPLTQ AELLAEAKVT
AEINLRSLEN YERLEADKKK QVHKKRQCVG PVIRYHSVLM PLVSDPSFKE ENVDVEGLDQ
DPQQSLPGSG SGAAVMSQSE ATLSGQPVSI SAPPPPGGGR CSRTYITFSD EDTFQSYFPK
TSAPRVPVKE VCPVTHKPAL YRDPITDIPY ANVRAFKIIR EAYKKYVAAH GLPCPGTTLP
AEPTAKSLRQ KIVIKQGI
//
