ID   A0A3B4C721_PYGNA        Unreviewed;       704 AA.
AC   A0A3B4C721;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Engulfment and cell motility 3 {ECO:0000313|Ensembl:ENSPNAP00000006691.1};
GN   Name=ELMO3 {ECO:0000313|Ensembl:ENSPNAP00000006691.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000006691.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000006691.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
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DR   AlphaFoldDB; A0A3B4C721; -.
DR   Ensembl; ENSPNAT00000003112.1; ENSPNAP00000006691.1; ENSPNAG00000012765.1.
DR   GeneTree; ENSGT00940000159455; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   CDD; cd13359; PH_ELMO1_CED-12; 1.
DR   Gene3D; 6.10.250.810; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51335; ELMO; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT   DOMAIN          297..467
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
FT   DOMAIN          529..647
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   704 AA;  80546 MW;  D388B1464ACEEC20 CRC64;
     MCASVCERER TALTTGLIRS TAVFYSFHLS DAQKCCQNLL LFFFSLRWNL SGPENFALQY
     ADGVQTYITE SGRCAEDLYK GIQSSDSGVR CESLKELAAV STDITFAQEF ISRDGHSLLV
     QIVEDANEVP MVMLHTLTAF MELMDHGIVS WENLSSVFIK KLVSFVNGKL LDASIQQVSL
     DIMESMVLSS SSLFHQIRKE ITLDQLISHL QVSNQLLQTK AMALLMALLQ TAGETDRQDL
     FAFLEKKNMR QYIYKNIIHS SGSVGDEMAH HLYVLQSVRL NLLEPRMKTP LDSFNQEQRE
     ALHSLRQAVF ETESEGSLSN ERRRSLCAKE FKKLGFSNNS NPGQDLGRTP PGLLALDTMT
     YFASRYPDAY SRFVLENSSR EDKHECPFAR SSIQLTLTLC EILRIGEPPS ETGSNYHPIF
     FAQDRLLEEL FCICIQLLNK TWKEMRATQE DFDKVMQVVR EQITRTLSSK PTSLELFKNK
     VNALNYSEIL KLRQTERLHQ EETLAPPVLE LKERLKPELL ELIRQQRLNR LCHGTLFRKI
     SSRRRQDKLW YCRLSPNHKV LHYGDVEEET ETPSIESLQD KIPVADIKAL LTGKDCPHMK
     ENKGKQTKML DLAFSITYDV EEYSLNFIAS SRTDFCLWTD GLNVLLGKEM SSEAMRSELE
     ILLSMEIKLR LLDLENVPIP DTAPPIPKPP SNFNFCYDFS QAEQ
//