ID A0A3B4C7L7_PYGNA Unreviewed; 1137 AA.
AC A0A3B4C7L7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSPNAP00000007155.1};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSPNAP00000007155.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000007155.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000007155.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017556270.1; XM_017700781.1.
DR AlphaFoldDB; A0A3B4C7L7; -.
DR Ensembl; ENSPNAT00000002336.1; ENSPNAP00000007155.1; ENSPNAG00000013023.1.
DR GeneID; 108429204; -.
DR CTD; 197358; -.
DR GeneTree; ENSGT00940000159861; -.
DR OMA; DFTQVET; -.
DR OrthoDB; 4632557at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF13516; LRR_6; 11.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 15.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
FT DOMAIN 201..332
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 365..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 123937 MW; 96AF06D4147ED0D7 CRC64;
MERNLQIPWQ EDCYMDLKST SPKSETRKKM EDAGWLLRHQ KSLQRFVSVS LLMDMVNHMR
KSEQLTAEDA SMIQGRGSLE DKVHTLVELL RISDPQGSTL QAYLQNSHPD EYNLVTLHDS
VVQQHKAVLR KRVDTESLTH QVTNHSHGPA LLLVEGVSDL QQREHDLIQV SVNRGTAPLH
GRPLGLDRLL APLTRVSTAP RVTLTVGVAG SGKTRLVHQF VRLWISGKIF PDLSLVIPVA
CWELSSFDRL SVERMLRSIV PYENVDVILN GGICKVLLIF DGLEEFRTPL DFSEAPATPD
PRRELLVSDL ITNIVRGNLL PGVTLWLLSR PGVGSKVPAG LVDRVTEVQP FTHTHIQDYL
TKSLTRSQEN SCMPSRPSTP SAPRSHASED TPHQVWDHLS CQKPVLILCS VPGICRIVTT
TLSHLVRAEL EDIPLPRTLT EIYAHYCWPH LTSADPSSGS IRKPLATLGR MAFYSLLRRR
HTFSEAELRT YGVDVPPPLG TLGHRVLQRE QSWSSECVSW RFVHTSVQEF LGALFYYTSS
RRGMFDLFSE SSVSWPRIGF PSHYRAALQK SNSAANGNLD FFMRFLSGLL SSAVGGLLGG
ALGVGREEQV TQRTMGTTLL QNTVVGSGGE AVSMRSIATV ACLAELQQGE WIRSVEEDLI
GCRLRGKLKG GVCAVLAYLL QVSDACVDET HLSNCLDSAS LKRLLPQLLY CSKLRMENNE
FKDDAMELLG SLLSAKDCRI QSLSLAENSI SSKGIKPLSR ALLVNRTLTV LDLHGNNIGT
KGAKVLAEAL KLNQVIVSVN LQSNSIEDEG ARALADVLQS NRKLTSLNVQ KNSIGPDGVK
RIADSLKKNQ ILQDLNVSSN HLGDLGTVAL AQALMVNHTL CTLRLQSNSV SDKGMKALTQ
ALRSNKGLTS LNLRENSIGV EGAKAIARAL QENNTLAELD LTANLLHDEG VTAIAGAVKA
NRALRSLHLQ WNFMKGGAAK ALARSLHSNT SIQLLDLQEN ALGDDGVVSL AAALRENSSL
AVLYLQGVSA GKAGAVALAE ALMVNQTLHT LDLRGNSIGM AGAKALSSAL KTNRSLRSLN
LQENSLGMDG AIFIATALRG NHQLTYINLQ GNGIGESGAK VVSDAIRADA SECVVDI
//
