ID A0A3B4CA80_PYGNA Unreviewed; 554 AA.
AC A0A3B4CA80;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Mucolipin 2 {ECO:0000313|Ensembl:ENSPNAP00000008513.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000008513.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000008513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017557871.1; XM_017702382.1.
DR AlphaFoldDB; A0A3B4CA80; -.
DR STRING; 42514.ENSPNAP00000008513; -.
DR Ensembl; ENSPNAT00000014621.1; ENSPNAP00000008513.1; ENSPNAG00000014149.1.
DR GeneID; 108430126; -.
DR CTD; 255231; -.
DR GeneTree; ENSGT00950000183036; -.
DR OMA; CDADRWE; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF4; MUCOLIPIN-2; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 273..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..259
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 361..497
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 554 AA; 63591 MW; BF10534F7688CC49 CRC64;
MELLDRKSDS TSIDMPVTLE PMMEETLRED LRYYFMSPCE KYRARRQLPW KLAVQILKIV
MITTQLVLFG LSNQLVVAYK EENLMAFKNL FLKSYSGVDE DDYSVAVYTK QSVIDNIFYV
LDQYSQLDQL SVGPVSYAEE NRRLLPLVIC KESYRPGRVE SSDESYDIDA QTEKVCLTWD
PKSIATWRTN SSTFFELDFY RLVNVEISFT LKGINLQTIS SHEPPDCYMF AVTITFDNQC
HSGKVKITLD LDAVSSACKN WKISGTAQKN THYLLIFDGF IILVCLTSAV LCIRSIVLAI
KLLQRFSKFC LKKYNRKVCE DDQREFLNGW YVLVIISDVM AIIGSVLKME IQAKSMTSYD
VCSIFLGTST LMVWVGVIRY LGYFQKYNVL ILTMQAALPK VLRFCCCAGM IYLGYTFCGW
IVLGPYHEKF EGLSRVAECL FSLVNGDDMF PTFAEFQQKN TLVWLFSRVY LYTFISLFVY
MVLSLFIALI TDAYETIKET RFPLTKLQLF LRTGKDFPLL EGEDDGGSRE NGGPSVMLCC
CTRVPKEDTT MLIS
//
