ID A0A3B4CA84_PYGNA Unreviewed; 757 AA.
AC A0A3B4CA84;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Eukaryotic elongation factor 2 kinase {ECO:0000256|PIRNR:PIRNR038139};
DE EC=2.7.11.20 {ECO:0000256|PIRNR:PIRNR038139};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000008852.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000008852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[translation elongation factor 2] + ATP = [translation
CC elongation factor 2]-phosphate + ADP + H(+); Xref=Rhea:RHEA:21436,
CC Rhea:RHEA-COMP:11268, Rhea:RHEA-COMP:11269, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546,
CC ChEBI:CHEBI:456216; EC=2.7.11.20;
CC Evidence={ECO:0000256|PIRNR:PIRNR038139};
CC -!- ACTIVITY REGULATION: Undergoes calcium/calmodulin-dependent
CC intramolecular autophosphorylation, and this results in it becoming
CC partially calcium/calmodulin-independent.
CC {ECO:0000256|PIRNR:PIRNR038139}.
CC -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|PIRNR:PIRNR038139}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type
CC protein kinase family. {ECO:0000256|PIRNR:PIRNR038139}.
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DR RefSeq; XP_017539725.1; XM_017684236.1.
DR RefSeq; XP_017539726.1; XM_017684237.1.
DR AlphaFoldDB; A0A3B4CA84; -.
DR STRING; 42514.ENSPNAP00000008852; -.
DR Ensembl; ENSPNAT00000035080.1; ENSPNAP00000008852.1; ENSPNAG00000014517.1.
DR GeneID; 108412273; -.
DR CTD; 29904; -.
DR GeneTree; ENSGT00940000157839; -.
DR OrthoDB; 317178at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004686; F:elongation factor-2 kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0061300; P:cerebellum vasculature development; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16967; Alpha_kinase_eEF2K; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR017400; eEF-2K.
DR InterPro; IPR047588; eEF2K_a_kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR45992:SF2; EUKARYOTIC ELONGATION FACTOR 2 KINASE; 1.
DR PANTHER; PTHR45992; EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR PIRSF; PIRSF038139; Elongation_factor_2_kinase; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR038139};
KW Calcium {ECO:0000256|PIRNR:PIRNR038139};
KW Calmodulin-binding {ECO:0000256|PIRNR:PIRNR038139};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR038139};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR038139};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|PIRNR:PIRNR038139};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR038139}.
FT DOMAIN 138..348
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 440..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 85703 MW; 47F466441EF710C4 CRC64;
MMADDELMFS MEEVGSLKRS SGVRTVHFGN SSSVDDDEDD FYICPITDDP ASPAKEVCNY
LKNIANSRPL SNSLPRNSFT YKNKNETEPE VQSVRFGSLT EKGRATWKHA IEKARAMPDP
WAEFHLEDVE TEPCIRYRYN AITGGWAQDQ VFIKMSSQPF GKGAMRECYR AKKLSNFSHS
SNWKSASNYV AKQYMETVGR DVYFEDVRLQ MEAKLWGEEY NRHRPPKQVD IMQMCVVEMT
SRPGKPVYHL EHYIEGQYIK YNSNSGFVRD DNIRLTPQAF SHFTFERSGH QLIVVDIQGV
GDLYTDPQIH TEKGTDFGDG NLGVRGMALF FHSHLCNKIC KSMGLTPFDM SPAESTQLDC
TNKLLLSAKT MLRGCEEQCG SPRVRTTSLS RMPPILSQLS ETSSADENIS DVDSIPCSPL
SLGLSADRSP KVWSFLNDMS ETDMDQKSSE NGGDSGYPSE RRSEGDLGEH NDRFRPVYSR
HYSESDEDSV RRKAVVNASK LSVTVNSPDC HTLTEEKWSF FHSSRAHIHR PSCVAVEVER
LNSLFLERKI GQSVLGKVHL AMVRYHEAGR FCEKDAPWDQ DSAMYHLERA AMCGELEAIV
ALGQCYLQLP HHVLPEIKLE DSMENRKKGF NLLLQAAEAG DRPSMTLVAR AFDTGNSLPP
DSTQDWKEAV RWYDCVLNMT DYDEGGEFDG MHDEPRYLLL AREAEMYQQG GFNLDADPQR
AGDLFTEAAD AAMEAMKGRL ANQYYMKAEE AWSAMEE
//
