ID   A0A3B4CAA4_PYGNA        Unreviewed;      2241 AA.
AC   A0A3B4CAA4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=ATP-binding cassette sub-family A member 1-like {ECO:0000313|Ensembl:ENSPNAP00000008180.1};
GN   Name=ABCA1 {ECO:0000313|Ensembl:ENSPNAP00000008180.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000008180.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000008180.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   STRING; 42514.ENSPNAP00000008180; -.
DR   Ensembl; ENSPNAT00000000586.1; ENSPNAP00000008180.1; ENSPNAG00000013884.1.
DR   GeneTree; ENSGT00940000154658; -.
DR   OMA; FMWNVIA; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd03263; ABC_subfamily_A; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC2_TM.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR   PANTHER; PTHR19229:SF248; ATP-BINDING CASSETTE, SUB-FAMILY A (ABC1), MEMBER 1B ISOFORM X1; 1.
DR   Pfam; PF12698; ABC2_membrane_3; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          873..1104
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          1888..2120
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   REGION          1261..1293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1261..1285
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2241 AA;  251704 MW;  6FBE449FA69E4516 CRC64;
     MSISTQLGLL LWKNFTYRRR QTFQLLIEIV WPLFIFFILI AVRLNYPPYE QHECHFPNKA
     MPSAGTLPWI QGIVCNANNP CFRHPTPGES PGVVGNFNDS IISRLFSDAK KILLYSQNDK
     SLDGHMLKLY LYSSGFRLKD FLNDNETLST FLIQNASFSE NTVHNVLQAN VNLEKVSFGV
     HLKDMCNTSS LEDFVNITDR KVAKLTQDII CSSSQNWLNQ AESLFMANLD FFKPIRVREE
     NHKQILASMR SWSDLRNEIL FLTQNATGSP SQMYQAVSRI VCGHPEGGGL KIKSLNWYED
     SNYKALFGNY NSSDEEPVSV YDNTTTPYCN NLMKTIETSP ISRMIWRALK PLLMGKILYT
     PHTPATQKII HEVNRTFQEL GVLRDLGGMW EETRPKAWNF MENSKEMNLV RTLLQNNATA
     TFFSTQLTGT QWSVQDVISF LSKQSEDTRP HGTAFTWRDV FNETDQAIMS ISRFMECVNL
     DKLEPVSTEE KLVNESLGLL DNRKFWAGIV FPDIDSNSSE LPPHVNYKIR MDIDNVERTN
     KIKDAYWDPG PRADPFEDLR YIWGGFSYLQ DVIEQSIIRA VTGTKEKTGV YIQQMPYPCY
     VDDIFLRVMS RSMPLFMTLA WMYSVAIIIK SVVYEKEARL KETMRIMGLD NGILWFSWFI
     SSLIPLLMSA GLLVLLLKMG NLLPYSEPGV VFLFLSSFAV VTIMQCFLIS TAFARANLAA
     ACGGIIYFTL YLPYVLCVAW QDYIGLPTKV IASLLSPVAF GFGCEYFALF EEQGVGIQWS
     NLFSSPMEED DYSLTTSIIL MYFDAFLYGV MTWYIEAVFP GQYGIPRPWY FPFTKSYWFG
     EGDQKLKPTI QGKKANAEAV CTEEEPTHLD MGVYIENLVK VYRHGKKLAV DGLTLGFYEG
     QITSFLGHNG AGKTTTMSIL TGLFPPTSGT AYIMGKDIRS ELSAIRQSLG VCPQHNVLFS
     MLTVEEHVWF YARLKGLPED AVRAEIDQIL YDTGLPHKRK SRTSELSGGM QRKLSVALAF
     VGGSKVVILD EPTAGVDPYA RRGIWDLLLK YRAGRTIILS THHMDEADIL GDRIAIISHG
     KLCCVGSSLF LKTHLGTGYY LTLVKKEPEA SLSSCRNSSS TVSYVKKDDE ASESSSDAGL
     GSDHESDAAT AIDISLISGL IIKHVPNARM VEDLGHEITY ILPYESAKDG AFVELFHDLD
     DHLADLSISS YGVSDTTLEE IFLKVAEDSG VDTEMMSDGT VPIRRRRRHA FGADHQSCLK
     PLTEDDRFDG NESEADPDSR ETDYLSGSDG KGSYQIQSWS LKRQQFVALL WKRFLYARRS
     RKGFFAQIVL PAVFVCIALV FSLIVPPFGK YPSLALHPWM YEDQVIFISD DAPEDASTQN
     LLAALLEGPG FGTRCMEGEP IPGANCTMGD EDWSVPEVPE SVLEVFRMQN WTMENPSPAC
     ECSCDGKKKM LPECPVSAGG LPPPVMKISE RDTLQNLTGR NISDYLVKTY AQIIGKSLKN
     KVWVNEFRYG GFSLGARSTQ LLPPAEEIDD AISRVREIFN LEKVTADRFL KSLSAFINGL
     DTKNNVKIWF NNKGWHSIGA FLNVMNNGIL RANLPPEKDP SKYGITAFNH PLNLTKEQLS
     QVALVTTSVD VLVSICVIFA MSFIPASFVV FLIQERVNKA KHMQFISGVQ PYLYWLASFI
     WDMCNYVVPA TLVIIIFVCF QQKAYVSSTN LPVLALLLLL YGWSITPLMY PASFLFKIPS
     TAYVVLTSVN ILIGINGSVS TFVLELFGNN EIGGINDILK NVLLIFPHFC LGRGLIDMVK
     NQAMADALER FGENRFRSPL AWDMVGKNLF AMAVEGVVFF IITVFIQYRF FFKPTPLSAK
     LSPVGEEDED VARERQRIVS GAGQGDILEL RELTKVYKRK QKPAVDRLCV GIPPGECFGL
     LGVNGAGKTS TFKMLTGDSV VTSGEAFLAR KSILREIDQV HQNMGYCPQF DAINDLLTGR
     EHLEFYAILR GVPEREVCEV AEWGIRKLGL VKYADKAAGS YSGGNMRKLS TAMALIGGPP
     VVFLDEPTTG MDPKARRALW NCIHSVIKEG RSIVLTSHSM EECEALCTRM AIMVNGRFRC
     LGSVQHLKNR FGDGYTIILR VAGLNPDLQP VIKFIESELP GSTLKEKHRN MLQYQLPSSL
     CSLAHIFSIL AKHKDILRIE DYSVSQTTLD QVFVNFAKDQ SDDHSDHSIR RKEHKEAVVD
     IPLFSSPVPL SRKEKPKESF V
//