ID   A0A3B4CAM1_PYGNA        Unreviewed;       865 AA.
AC   A0A3B4CAM1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSPNAP00000008987.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000008987.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000008987.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B4CAM1; -.
DR   STRING; 42514.ENSPNAP00000008987; -.
DR   Ensembl; ENSPNAT00000015232.1; ENSPNAP00000008987.1; ENSPNAG00000014570.1.
DR   GeneTree; ENSGT00940000166814; -.
DR   OMA; RTMIFCT; -.
DR   OrthoDB; 3780425at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR   CDD; cd06364; PBP1_CaSR; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF546; OLFACTORY RECEPTOR C FAMILY, U1 PRECURSOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..865
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017194051"
FT   DOMAIN          601..865
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   865 AA;  95476 MW;  C5324F0479409058 CRC64;
     MPVCELVLLA LFLLFVHRAE SLESCRRLGE FVPQVLEVDG DVILGGLFPL HYMAPEPDHT
     FTDRAKFKRC SGFDLRAFRW AQTMVFAIEE INRNPDLLPG VTLGYRILDS CDHVHTSLQS
     VLSLVNGSSA LEIEESAASS SRSTRCLSRA PVPAVIGLAS STPTRAVAHI LGPFEIPLIS
     YFATCTCLTD KRVYPSFLRT VPSDVFQVRA LVQLMAHFGW RWVGTIGTDE DYSHYGIQAF
     TKQLEEWGGC VDFHRTIPKV PTPAQIYAIV DALEASTARV VVVFATEGQL LELLSEVAQR
     NLTGWQWVAS EAWVTAKILT APEFQHVLAG TLGFSFRGVR IFGLSEFLLS VRPSPDSRSV
     FTNQFWEEQF GCHLTYGDSE IMGRPLCTGL EDLGLVESSY TSASPARVSY NVYKAVYAIA
     HALHSLLRCT PVGSDWKGCN TESEFTPGQL LRQLKRVSFT SQFGEKVYFD ENGEPVPLYD
     IINWQRDDRG KIQFQRVGSF DGSAPHGQQL EMEQNSIEWT GGQSQAPVSL CTSLCPPGTR
     QATRPGKPVC CFDCLPCAEG EFTNTSGSIE CIKCPMYYWS NAERVACVAG IEEFLSFHEI
     MGIILVTLSL LGVGVATAVS VIFFLFRATP IVKANNSELS FLLLLSLKLC FLCSLVFMGR
     PSLWSCQARQ AAFGISFVLC ISCILVKTIV VLLAFRSTMP GSASLKRFGP PQQRAFIVAC
     TAGQAVLCMG WLALAPPVPY KNTSYQGGRI VLECKDVWPL GFYMVLGYIG LLSCVCFVLA
     FLGRKLPGTF NEAKLITFSM LIFFAVWISF IPAYNSTPGK YTVAVEIFAI LASAFGLLFC
     IFAPKCYIIL LRPELNTKKG MTGKI
//