ID A0A3B4CBP4_PYGNA Unreviewed; 1655 AA.
AC A0A3B4CBP4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Nidogen 2 {ECO:0000313|Ensembl:ENSPNAP00000008311.1};
GN Name=NID2 {ECO:0000313|Ensembl:ENSPNAP00000008311.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000008311.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000008311.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPNAT00000000355.1; ENSPNAP00000008311.1; ENSPNAG00000013969.1.
DR GeneTree; ENSGT00940000157901; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 7.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352:SF3; NIDOGEN-2; 1.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 7.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 4.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00211; TY; 7.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 7.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 7.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1655
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017455845"
FT DOMAIN 99..264
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 415..455
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 459..688
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 690..731
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 732..774
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 775..811
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 823..892
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 902..971
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 981..1050
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 1060..1129
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 1139..1208
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 1218..1287
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 1300..1368
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 1438..1481
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1482..1524
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1525..1569
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 290..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..313
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 861..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 940..947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1019..1026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1098..1105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1177..1184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1256..1263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1338..1345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1655 AA; 182515 MW; 0531FAF3C7188B0D CRC64;
MWSRAAELLL QLAWTACCVT AIQRKDLFPY GPLNGDLTLP EGDDETSKVM TLTKPMYFYE
TAFSNLYVAT NGIISTQDLP MEKQYVDDGF PTEFPVIAPF LADIDTSNGK GAIYYRQTEA
PGVLNRVAAE VQRGFPGSQF TPTHAVIATW ENVAAYEEVS RSSELRVNTF QAVVAYDEVN
TYALFLYPED GLQFYGTRPK ETFNVEIELT ARVGFTRGEV SYFFFSRTEG PYYSITTNEQ
SVKNLYQLSN VNVPGIWLFH IGNSYAFENV IPAAVSGQLP TTLPRKQVIE FPTTSEYPET
DDSFDDEQEY TEDPDFQNPS VPDFTEPGRD RSHLQPYGGD VTLTSNPQTH DAAPAITGPG
EYPPSETIPE VVQQQRPLPE RTFLEMNPHA TDGHVVSVEE DLDFDSGVIH YSTENKETCE
RFQQHCSQNA FCTDYPSGYC CHCHSGFYGN GRHCLPNGAP QRVNGKVRGT VNVGLSAVRL
DNIDLHAYIV VGDGRAYTAI SEVPEPLGWA LMPVAPIGGL FGWLFALKLP NSHNGFNITG
AEFTRHADVT FYPGNQRLSI VQTGRGLDDQ NYLNVDTHLE GSVPFIPPGA TVQMEPFKET
YQYYPSLITS SSVREYTVVS AESGAETFNY QLRQNMTYRD CRHGHRSGAE TLQLNVERIF
VMFVKEERIL RYAITNKIGH VGAGEVDPEQ VNPCYSGNHD CDTTAQCLPG EGNTFTCQCA
TGYTGDGRSC YDVDECVEGL SSCGSHSECV NLAGSHTCRC QSGYEFGYDG RSCLDVDECR
TQPCHPHASC SNTPGSFHCR CQHGFHGDGF QCHPQTVHPE RPETQCERHR DSLQSGSGGV
PLVGAFIPQC DDYGQYRPLQ CHGSTGYCWC VDSRGQERAG TRTPPGSSPT NCDAPVHPER
PKTQCEQHRD SLQSGSGGVP LVGAFVPQCD EQGRYRPQQC HGSTGHCWCV DSRGQERAGT
RTPPGSPPTN CDAPVHPERP KTQCEQHRDS LQSGSGGVPL VGAFVPQCDE EGRYRPQQCH
DSTGHCWCVD SRGQERAGTR TPPGSPPTNC DAPVHPERPK TQCEHHRDGL QSGSGGVPLV
GAFIPQCDEE GRYRPQQCHD STGHCWCVDS RGQERAGTRT PPGSPPTNCD APVHPERPKT
QCEHHRDGLQ SGQAGVPLVG AFIPQCDEEG RYRPLQCHGS TGHCWCVDSR GQERAGTRTP
PGSPPTDCNA PVHPERPKTQ CEQHRDSLKS GSGRTPLAGA FIPECDEEGQ YRPLQCHGST
GHCWCVDSRG QERAGTRTPP GSPPTDCDAP VESLPLPRPE TVCERWRASL MEHYGAQRSP
QQYLPQCDSA GEFNPVQCYG DSSYCWCVDK DGREVPGTRS NDAIKPACIQ TVTPPTRHPL
PRPDVTPPPS GTSLLYAQGQ KIGALPLNGT RMDKERSSVL LALHGSIVVG IDYDCRERKV
YWTDLAGRTI SRAALEPGAE PEILINTGLM SPEGLAVDAA RRRLFWVDST LDKIETANLD
GSDRQILFDT DLVNPRAIIV DSPSGALYWS DWNREAPKIE SSTVDGHNRR VLVRDGIGLP
NALTFDSAAR RVCWADAGTK RLECITPDGT GRRIIHSNLN YPFSMVFYAN HFYYTDWRRD
GVIAVSRDSS QFTDEYLPDQ RSHLYSITVA STSCL
//
