ID A0A3B4CEB3_PYGNA Unreviewed; 453 AA.
AC A0A3B4CEB3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Vitronectin {ECO:0000313|Ensembl:ENSPNAP00000009216.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000009216.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000009216.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017559866.1; XM_017704377.1.
DR AlphaFoldDB; A0A3B4CEB3; -.
DR STRING; 42514.ENSPNAP00000009216; -.
DR Ensembl; ENSPNAT00000035227.1; ENSPNAP00000009216.1; ENSPNAG00000006680.1.
DR GeneID; 108431314; -.
DR CTD; 403026; -.
DR GeneTree; ENSGT00530000063751; -.
DR OMA; FGAEESC; -.
DR OrthoDB; 5310951at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 2.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF3; VITRONECTIN; 1.
DR Pfam; PF00045; Hemopexin; 3.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 4.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF50923; Hemopexin-like domain; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 4.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..453
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017365092"
FT DOMAIN 17..59
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 107..151
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 152..199
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 200..250
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 390..444
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 309..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 51823 MW; 1F3F510DFA36C94A CRC64;
MKAVLLLLLG LATAFAAEET CAGRCQNGFD PTKKCQCDSM CKYYGSCCPD FETSCKSKTR
GDVFDFTEED LNTTVIPTAV MNTTTAAPSP TPVSTVSPDP EAVTCSGRSF DAFLQLKNGS
IYAFRGDYFF EMDERSVMPG YPKLIKDVWG ISGPIDAAFS RINCQGKTYI FKGNKYWRFD
TDVLDDDYPR DISVGFEKIP DDVDAAFAIP APGHHGKEKV YFFKGDQYYQ YEFKHQPSHE
ECIEMTKMSP SVLFTSYTNL YCDHDWDNLF TLLFQGLEGH HRGPRFIAKD WVGIKPPIDA
AMVGRLYEGS KPSTSPTSST DAVVVPSRRR SSRRRKHKGK GSKIQSRSLF WEDYGLDYEE
RYFGAERRGK DQRKGRGRRP SLDDYSYDLT DYTDLEIVQE KTMPVQNVYF FKKDKYYRVD
LQTKRVDYAN PPYPRSIGKY WLGCKEKDLA EKR
//
