ID A0A3B4CF07_PYGNA Unreviewed; 739 AA.
AC A0A3B4CF07;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sodium/potassium/calcium exchanger 1 {ECO:0000256|ARBA:ARBA00040585};
DE AltName: Full=Na(+)/K(+)/Ca(2+)-exchange protein 1 {ECO:0000256|ARBA:ARBA00042035};
DE AltName: Full=Retinal rod Na-Ca+K exchanger {ECO:0000256|ARBA:ARBA00042297};
DE AltName: Full=Solute carrier family 24 member 1 {ECO:0000256|ARBA:ARBA00042684};
GN Name=SLC24A1 {ECO:0000313|Ensembl:ENSPNAP00000009451.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000009451.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000009451.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR RefSeq; XP_017547084.1; XM_017691595.1.
DR AlphaFoldDB; A0A3B4CF07; -.
DR STRING; 42514.ENSPNAP00000009451; -.
DR Ensembl; ENSPNAT00000015813.1; ENSPNAP00000009451.1; ENSPNAG00000003338.1.
DR GeneID; 108423923; -.
DR CTD; 9187; -.
DR GeneTree; ENSGT01030000234532; -.
DR OrthoDB; 22570at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF36; SODIUM_POTASSIUM_CALCIUM EXCHANGER 1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 181..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 186..327
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 578..726
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 41..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..537
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 81968 MW; A37A358B926A8BA3 CRC64;
MYLTRRKRLQ LSRIIFLLSG VLLCCIYQLT IRTRLPEPWA EPQVGEQPED GPEGGLEKAT
QGLLEKPETT VKLSTTAVEL EVTTHTDVVH SEETPATTMA PPKAETTETT ELTTLTTTNR
TIIHCIYVDP DLPKPTPAPT PAPETTTPTQ PTTAASPAKP PHMKGEYPED IFSVDERRRG
WVVLHIFGMI YMFVSLAIVC DEFFVPTLGV ITDKLEISDD VAGATFMAAG GSAPELFTSL
IGVFISHSNV GIGTIVGSAV FNILFVIGMC ALFSREMLYL TWWPLFRDVS FYILDLIMLI
IFFLDNTIMW WESIMLVGGY ATYVYFMKYN VQIERAFKAQ LHKHKNIVKV IAVEEPEKEN
GTSTDDNAPP EPPEDKNRLK LKPTLQRGGS SASLHNSTMR NTIFQLMIHT LDPLGEVKFK
DKAQILNNMA RGKVEGKEKE KGTGEDGKEQ PKDSKEPAAS KEEGSKDKAE GQKDEPEAAA
EKGDTEASGG SDDSEEDDSD EDSDEDSDDD DDDDNEEDEA DEDDGGEADG EENDEPLSLE
WPDTRRKQAT YLFLLPIVFP LWLTVPDVRN PASKKFFVIT FLGSIMWIAI FSYLMVWWAH
QVGETIGISE EIMGLTILAA GTSIPDLITS VIVARKGLGD MAVSSSVGSN IFDITVGLPV
PWLMYASFHG LEPVAVSSNG LFCAIVLLFL MLLFVIISIA VCKWRMNKML GFTMFMLYFV
FLVLSVMLED RIIVCPVSI
//
