ID   A0A3B4CGN0_PYGNA        Unreviewed;       266 AA.
AC   A0A3B4CGN0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Dickkopf WNT signaling pathway inhibitor 3 {ECO:0000313|Ensembl:ENSPNAP00000009609.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000009609.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000009609.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
CC       {ECO:0000256|ARBA:ARBA00010842}.
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DR   AlphaFoldDB; A0A3B4CGN0; -.
DR   Ensembl; ENSPNAT00000035389.1; ENSPNAP00000009609.1; ENSPNAG00000015091.1.
DR   GeneTree; ENSGT00390000000221; -.
DR   OMA; ERECCHG; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR   CDD; cd23274; Dkk3_Cys2; 1.
DR   Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK1-4.
DR   InterPro; IPR047300; Dkk3_Cys2.
DR   PANTHER; PTHR12113:SF8; DICKKOPF-RELATED PROTEIN 3; 1.
DR   PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..266
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017445494"
FT   DOMAIN          135..185
FT                   /note="Dickkopf N-terminal cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF04706"
FT   COILED          45..72
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   266 AA;  29114 MW;  32A7DB9E98C95A99 CRC64;
     MHVLELSVCL AVTSAIAAAN AVHADLNGTV EADGARGQTT LGDMFREVEE LMEDTQHKLE
     DAVHQMDNES AKSSQHVQNF ASHFNNESSS EIVLGNQSTP AVGKIDKILE NRTEETHISR
     TIIQTNGKEN DTNHECVIDE DCEKGSYCLY EVNHSKCLAC KEVNATCTKD EECCEGQLCV
     WGQCTKNTTK GEAGTICAYQ SDCSSGLCCA FHKALLFPVC ISKPTERERC LISASHLMDL
     LSWDLEGEGP REHCPCTGDL QCQHLG
//