ID A0A3B4CGT3_PYGNA Unreviewed; 909 AA.
AC A0A3B4CGT3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK2 {ECO:0000313|Ensembl:ENSPNAP00000010663.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000010663.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000010663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. GRIK2 subfamily. {ECO:0000256|ARBA:ARBA00038119}.
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DR RefSeq; XP_017563713.1; XM_017708224.1.
DR RefSeq; XP_017563714.1; XM_017708225.1.
DR AlphaFoldDB; A0A3B4CGT3; -.
DR STRING; 42514.ENSPNAP00000010663; -.
DR Ensembl; ENSPNAT00000035803.1; ENSPNAP00000010663.1; ENSPNAG00000016277.1.
DR GeneID; 108433570; -.
DR CTD; 2898; -.
DR GeneTree; ENSGT00940000155610; -.
DR OMA; YHRWREV; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF38; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Signal {ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 33..909
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027165919"
FT TRANSMEM 564..583
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 640..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 821..845
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 433..802
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 443..508
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 909 AA; 102834 MW; B72451F51CF0C713 CRC64;
MKITSPLITH ARFRCCVRLL LLPLLCVGYS RGMPHVLRFG GIFESIETGP SGAEELAFKF
ALNTINRNRT LLPNTTLTYD IQRINIHDSF EASRKACDQL SLGVAAIFGP SHSSSANAVQ
SICNALGVPH IQTKWKHQVS DNRDSFYVSL YPDFSSLSRA ILDLVHFFKW RMVTVVYDDS
TGLIRLQELI KAPSRYNIRL KIRQLPAETK DAKPLLKEMK RGKEFHVIFD CGHEMAAGIL
KQALAMGMMT EYYHYIFTTL DLFALDVEPY RYSGVNMSGF RILNTENSQV SSIIEKWSME
RLQAPPKPDS GLLDGFMTTD AALMYDAVHV VAVAVQQSPQ ITVSSLQCNR HKPWRFGNRF
MTLIKEAHWD GLTGRINFNK TNGLRTDFDL DVISLKEEGL EKIGTWDPVS GLNMTEHQKG
KMANVSDSLT NRTLYVSTIL EEPYVMFKKS DKPLHGNDRF EGYCIDLLRE LANILGFVYE
VRLVEDGKYG AQEESTGQWN GLVRELMDHK ADLAVAPLAI TYVREKVIDF SKPFMTLGIS
ILYRKPNGTN PGVFSFLNPL SPDIWMYILL AYLGVSCVLF VIARFSPYEW YNPHPCNPDS
DVVENNFTLL NSFWFGVGAL MQQGSELMPK ALSTRIVGGI WWFFTLIIIS SYTANLAAFL
TVERMESPID SADDLAKQTK IEYGVVEDGS TMTFFKKTKI STYDKMWEFM SSRRHSVMVK
SVEEGIQRVL TSDYAFLMES TTIEYVTQRN CNLTQIGGLI DSKAYGVGTP MGSPYRDKIT
IAILQLQEEG KLHMMKEKWW RGNGCPEEES KEASALGVQN IGGIFIVLAA GLVLSVFVAV
GEFLYKSKQN AQLEKRSFCS AMVEELRVSL KCQRRLKHKP QPPVMVKTEE VINMHTFNDR
RLPGKETMA
//