ID A0A3B4CHA3_PYGNA Unreviewed; 310 AA.
AC A0A3B4CHA3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Retinol dehydrogenase 8-like {ECO:0000313|Ensembl:ENSPNAP00000010833.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000010833.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000010833.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484, ECO:0000256|PIRNR:PIRNR000095,
CC ECO:0000256|RuleBase:RU000363}.
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DR RefSeq; XP_017557035.1; XM_017701546.1.
DR RefSeq; XP_017557036.1; XM_017701547.1.
DR RefSeq; XP_017557037.1; XM_017701548.1.
DR RefSeq; XP_017557038.1; XM_017701549.1.
DR AlphaFoldDB; A0A3B4CHA3; -.
DR STRING; 42514.ENSPNAP00000010833; -.
DR Ensembl; ENSPNAT00000017607.1; ENSPNAP00000010833.1; ENSPNAG00000016437.1.
DR GeneID; 108429652; -.
DR GeneTree; ENSGT00940000165414; -.
DR OMA; ACCEESI; -.
DR OrthoDB; 2898074at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IEA:InterPro.
DR GO; GO:0006703; P:estrogen biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR011348; 17beta_DH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43391:SF1; RETINOL DEHYDROGENASE 8-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR43391; RETINOL DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR PIRSF; PIRSF000095; 17beta-HSD; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT ACT_SITE 154
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000095-1"
FT BINDING 10..38
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000095-2"
FT BINDING 64
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000095-2"
FT BINDING 141
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000095-2"
FT BINDING 158
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000095-2"
SQ SEQUENCE 310 AA; 34743 MW; 88EDB6257334AE48 CRC64;
MGTRRVLVTG CSSGIGLAIA VRLAKDELRR FKVVATMRDV EKRGALEIAA GETLSRTLEI
RQLDACCESS IRECVNSLPE RRVDVLVNNA GMGMIGPLEC QSVKDMQDLF NTNFFGLVRL
VKEVLPDMKR SQSGHIVVMS SVMGVQGLLF NDVYAASKFA VEGFCESLAV QAMKFNIKMS
LVEPGPVVTE FEKKVYEEVQ NMDLSCTDEE TARIFREIYL PYSRKVFSSL GQTPEEVAEQ
TLQLIVAKNP PFRHQTNRLY TPLTAMKHAD PTGRLPIDAF YKMVFQHDRV FNASLGVMRM
LQKRMGKSKA
//
