ID A0A3B4CJM5_PYGNA Unreviewed; 1447 AA.
AC A0A3B4CJM5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Nuclear factor of activated T-cells 5-like {ECO:0000313|Ensembl:ENSPNAP00000010719.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000010719.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000010719.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017554929.1; XM_017699440.1.
DR STRING; 42514.ENSPNAP00000010719; -.
DR Ensembl; ENSPNAT00000017472.1; ENSPNAP00000010719.1; ENSPNAG00000016335.1.
DR GeneID; 108428435; -.
DR CTD; 334390; -.
DR GeneTree; ENSGT00940000155213; -.
DR OMA; LPMGQQS; -.
DR OrthoDB; 5405363at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 269..443
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 37..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 796..841
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 885..922
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1447 AA; 156506 MW; D4A25C0E200F378E CRC64;
MPSDFISLLS TDIDLNSPKS LYSKESVYDL LPKELQLPPT TQDKQTMSQK SGGEAGPLPS
AALASDAATA SSSPGGHSSA LPASSSMHST TSAPEQSSRL HSCLPAEVLG AEPSSASAIS
GVAGGDGVGV PAHQNQMTPS KRRTVLNISP PPEDLLDDSR MSCQDELPLN PDSEQSSSIW
MDDSVSNFSM LSNSSYNDNT EVPRKSRKRT PRQRPGPKPV ARDEATMDVF DADSAKAPHF
VLSQLGSEAK GNLKGSTLEV AGSQKGGVLS MQYPQKSEGK ELKILVQPET QHRARYLTEG
SRGSVKDRTQ QGFPTVKLEG VNEPVVLQVF VANDAGRVKP HGFYQACRVT GRNTTACKEV
DVEGTTVIEV NLEPSNSMTL AVDCVGILKL RNADVEARIG VAGSKKKSTR ARLAFRVNIP
RPDGSVLTLQ TLSSPILCTQ PAGVPEILKK SLHSCPVIGG EEIFIIGKNF LKGTKVIFQE
NATDDSSWQA EAEIDMELFH QNHLVVKVPP YHDLTVTSPV SVGISVVTNA GRTHELQPFT
YTPQQEKADI SVKSELPATS KPCTFEDQIT AMQSGTSSLN STLMAPMISI VKREEVTPME
VSTNPTACNI FKPAEVLNSN QQILEITTVL PTSSKSFPSP VPLQPVDSQQ SAPPIFTAPE
PLTTIQKQDI SPTTSFQVSL SEDTTVLQPV PPQVPQQFLR ETPETLSPED NSPDGTGMVV
VSMESRPPPS QQPQVQNLLP QDEVAQLERA VRELQEQQQL NSVLYGPTPS AESLQQHVQE
NMNSLRLGGN ENTLTNQQQQ QQEQNILENL QQQHQKALVD LQHQQTVLES LQQQQKVLEN
LQHQALGSLQ QQQSHQKVLE NMQHQKVLED IQQQNSLVNM QHQKVLNTLQ QQQQHQKNLE
KLQQEQQHQE VLENLQKHLQ SELPQIPMQC TPSFSGVPPD QISEHQSTTQ TDGTMSQPSD
GFLQNSSQQP QQQALFQQAG GILTIQTSSF LQQSPSQSSP PQQLFQSHNP MTETQDPQTA
LFGSSKASQV QPALFPNTLT MLTSTNLSSE QQAPSTTLFI SQGVLPSQIT ADSTQNQQQQ
QITFLTPMPP SASAQTVSLF QGQAQLSTPM EQQQSPQPQQ IPTPQQASLF QSMSTISQSQ
AQQPSQTGLL FCATPINPQD LPQTLLFSGQ NQGPIGGEQL PQNIFQDQQP MQVVPSSANV
AADTSTNQST VPSQSNQSPQ ILFPQASVVN VAQQDSSEPM SFQDESSVVD DSATSMPSTR
PGLFQDQQPM QVVPSASNVA SVSSTDQASV NIFLPQAAIS ALQSGVGTQE LPQAATAAAI
FSGQGGVAIG GLQSSTPTSS QPTPDPLFQT ALGNTLSQPG QPGQPGLFLF EIPNECGQLL
NPSGPALADR LVSMGHPSSD HNQSQLQTSA QIHTLLDQSS NLNEKIDELL ERFQEQGKTL
SRNFLEQ
//
