ID A0A3B4CJR5_PYGNA Unreviewed; 1232 AA.
AC A0A3B4CJR5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Probable G-protein coupled receptor 158 {ECO:0000313|Ensembl:ENSPNAP00000011071.1};
GN Name=GPR158 {ECO:0000313|Ensembl:ENSPNAP00000011071.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000011071.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000011071.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3B4CJR5; -.
DR STRING; 42514.ENSPNAP00000011071; -.
DR Ensembl; ENSPNAT00000017975.1; ENSPNAP00000011071.1; ENSPNAG00000016692.1.
DR GeneTree; ENSGT00940000155918; -.
DR OMA; TMECKPV; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF27; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1232
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017355128"
FT DOMAIN 354..624
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 674..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..689
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 137233 MW; 096540C7AFA3BABD CRC64;
MGALLLWLLV QTGLLQGSSY VYGYGYVDWA DSENARGDAE APQRPTVRAT VAHRLEEDVP
KVVAAFLHTG DSSALAQANC SRRYELGGLR ASSSSTSRHS LRTAVEAVVR AAGLLNGLLP
LGDGQPQRDA VWYGALVRSL LDADLRIHRA ALALQAKPRL LLQATRSGGH VAVRDLKESE
WHDEFRERKR VHGPRGQGPE PGEIKWSAPY LECEGGSFVP HWLLTLSSGI YAPGTDAAAP
DFRGVVRVDV NLQDEDIDQC SSSGWFAGTH RCNLTTMECK PVPGHGFILD KYKCQCKRGF
YSPSRVALNG VSKSEQGLYS DEPSDVSPRC LPCREGCSFC RDDSPCLAQE DGVLRVAVAS
FQGLCMLLDF ISMPVVYHFR RNKRIKASGL ILLEAIMAGA VLLYFPVMIL YFQPSVFRCI
LLRWVRLLGF ATVYGTVILK LYRVLKVFLS RTAQRIPYMT SWRVLRLLAA ILLVVLWFLV
AWTLAMCQST DIHHTLVDMG VTPEGLHFNM CLLDRWDYMM AVAEFLFLLW GVYLCYAVRT
VPSAFHEPRY MAVAIYNELL ISAIFHIIRF TLAPGLHPDW MLMLFFVHTH LTVTVTLGLL
LIPKFLFTGT HMQDDIATEA YEDELDMGRS GSYLNSSITS AWSEHSLDPE DIREELKKLY
SQLEIYKRKK MLANNPHLQK KRSSKKGIGR SLMRRITEIP ETVSRQYSRE DRDGSEHGSN
RSTLRRNPFE PSHGGKSREE SLKNRMFSLK RSHSYDHSHD QGQNANGGPA DKLENSTTEL
SLLGTLMGRR SAKKNPEMPK VEPAESAESV PLVCKSVSAH NLAADKKPVH LRTSMLQKSL
SVIASARERT LGLAGKTHSV EDASKKGLKS RDTRMLSEVD ESPECFPKMI ISQSVEYTKT
PSKMGIMKQQ VSGSQPSICS EPGRSKDLYD LSEVCPWEME DLPTPSEGKA QKHVSIAPSE
TTTIHGSSYK SGRSQHKQKT AIQSPSNRRR SRDKGSTRED ESDKHEGRKP KSPLKLTAHK
GDICPWEFED PSSKGLESEI TSRKKSVTPT DGNPKMILSD ISKSTGSLLQ PPAFMVEICP
WDYDQPPSPN QEKTSSPTHH SKRRDSNTKR KGSCSSKVKG KDKEDDKQRS KSKERRSSSS
KPSEKRRISQ TSDSSQATTT VSGRRRSSTR EVGITDSKRA EACPRETECV PSVTSRDKYS
SARDNHTASQ TTTTTAAAGA SKLNMAEDHD AS
//
