ID A0A3B4CJT4_PYGNA Unreviewed; 849 AA.
AC A0A3B4CJT4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000011091.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000011091.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR RefSeq; XP_017580701.1; XM_017725212.1.
DR AlphaFoldDB; A0A3B4CJT4; -.
DR STRING; 42514.ENSPNAP00000011091; -.
DR Ensembl; ENSPNAT00000017948.1; ENSPNAP00000011091.1; ENSPNAG00000017470.1.
DR GeneID; 108444191; -.
DR CTD; 561117; -.
DR GeneTree; ENSGT00950000182881; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 409..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 548..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 578..601
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 779..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 849 AA; 97320 MW; 70BC0BA395DCC085 CRC64;
MGSLFRSEEM CLAQLFLQSG SAYDCISELG ELGLVEFRDL NPSVNAFQRK FVNEIKRCED
MERILGYLLR EIKKADIALP EGEVNPVAPL PKHVMDIMEQ LQRLELELSE VTRNKEKLQK
NLLELTEYTH MLRITRNFVH RNAERESVRP QYEEFPFLEK DVVMDYSSMQ RLGAKLGFIS
GLIQRAKIEA FERMLWRVCK GYTILSYAEI DECLQDPYTG ESTRSVVFLI SYWGDQIGQK
VKKICDCYHC HLYPYPNSNE ERADVVDGLR TRIQDLHTVL HRTEDYLKQV LNKASESVYT
WGIQVKKMKA IYHILNLCSF DVTNKCLIAE VWCPVNDLPA LRRALEEGSR KSGATVPSFV
NRIPSNDTPP TLIRTNKFTS GFQNIVDAYG VGSYREVNPA PYTIITFPFL FAVMFGDLGH
GVIMAVFALW MVLYENDRKL KKTRNEIWNT FFEGRYIILM MGIFSVYTGF IYNDCFSKSL
NLFGSGWNVK AMFDHGPWKM DTLQSNSFLT LDPNVTGVFT GPYPLGIDPI WNLASNRLSF
LNSYKMKMSV ILGIIHMSFG VILGVFNHLH FRRKYSLYLV FLPELLFLLC LFGYLVFMIV
YKWLAFTARE SEKAPSILIQ FINMFIMQEG SGEPLYPGQA GLQVFLVLIA VLSVPVLLLG
KPLYLYWLHK GRNNMGMYRG YERVRRSSEE EISLMRAHDL EEGNSLDSHS SSSDGQSEEL
DFADVFLHQS IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWAMVMR VGLRVDTRVG
VLFLVPVFGL FAVLTVSILL VMEGLSAFLH ALRLHWVEFQ NKFYSGAGTK FSPFAFSLLH
ASFESHGLL
//
