ID   A0A3B4CKV1_PYGNA        Unreviewed;       819 AA.
AC   A0A3B4CKV1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSPNAP00000011978.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000011978.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000011978.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B4CKV1; -.
DR   Ensembl; ENSPNAT00000019116.1; ENSPNAP00000011978.1; ENSPNAG00000017707.1.
DR   GeneTree; ENSGT01100000263565; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF504; EXTRACELLULAR CALCIUM-SENSING RECEPTOR ISOFORM X2-RELATED; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        543..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        580..602
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        614..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        658..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        703..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        738..758
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        770..793
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          544..808
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   819 AA;  90868 MW;  614D3FE1EAC3847B CRC64;
     MSQSVTEKGS CSKNKQNNLT LLFRTSNLLP SFEIISLRFH FLAVYIEIRY SGSVLMLLFT
     FSIYSFDPRA FRWALTMKLA VEEINNSTEL LPNHTLGYKI FDSCAYPLTG QRAALAVMNG
     PNEADRPMCS GASPMLAIIG ESGSAHYFSS CACLSNRQEF PTFFRVIPSD AYQVKAIAKL
     LLHFNWTWVG VVRGDHEYGR SALQGLLKEL EGTGVCVAYQ EMIPLLYNSQ RAVEIFRVMN
     SSSARVVVVF SAEGELTPFL RDYMELNVTG IQWIASEAWV TAAVFTGSKY YPFLGGTIGF
     GIRQGYIPQL REYLTTVNPQ RYPTNPLVQE LWGALYGCSP FSSDGAQLPL CTGHETISKQ
     HSAYMNTSSP RIAYNVYKGV YAIAHSLHNL ISCNPGNGPF INSTCAHVTK LQHYLQEVSF
     TISGEMVNFD TKGDSIPSYD LINWQKVYIN LLHLYRSLLT PDCCVCGKQV PVSVCSFSCA
     PGFRKAVRRG EPLCCFDCVP CDSGKISNQT DSIDCIPCSE DYWSNIDGTA CIPKVVEFLS
     HDAMGVTLTV ISVAGACVTL AVFAVFLYHR NTPIVRINNS ELSFFILISL TLCFLCALIF
     IGEPTSWSCM LRHTAFSITF SLCISCILGK TLVVLAAFTA TRPGNNVMKW LGPTQQRIII
     FSCTLVQMII CAAWLIASPP FPYRNTQYQH SKIILDCSVG SALAFWCVLG YIGFLAGLCF
     ILAFLARKLP GNFNEAKYIT FSMLIFCAVW LAFVPAYVSS PGKFTTAVEI FAILASSFGL
     LSCLFAPKCY IILLKPEKNS KHHQHTNPWC SSLHYILTA
//