ID A0A3B4CLU5_PYGNA Unreviewed; 338 AA.
AC A0A3B4CLU5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Potassium inwardly rectifying channel subfamily J member 15 {ECO:0000313|Ensembl:ENSPNAP00000012320.1};
GN Name=KCNJ15 {ECO:0000313|Ensembl:ENSPNAP00000012320.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000012320.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000012320.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR RefSeq; XP_017546874.1; XM_017691385.1.
DR RefSeq; XP_017546875.1; XM_017691386.1.
DR RefSeq; XP_017546876.1; XM_017691387.1.
DR AlphaFoldDB; A0A3B4CLU5; -.
DR STRING; 42514.ENSPNAP00000012320; -.
DR Ensembl; ENSPNAT00000036467.1; ENSPNAP00000012320.1; ENSPNAG00000018049.1.
DR GeneID; 108423803; -.
DR CTD; 3772; -.
DR GeneTree; ENSGT00990000203615; -.
DR OMA; GYGFRHI; -.
DR OrthoDB; 4126787at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR041647; IRK_C.
DR InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR InterPro; IPR040445; Kir_TM.
DR PANTHER; PTHR11767:SF20; ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15; 1.
DR PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; PF17655; IRK_C; 1.
DR PIRSF; PIRSF005465; GIRK_kir; 1.
DR PRINTS; PR01320; KIRCHANNEL.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003822};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU003822};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003822};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003822}.
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..150
FT /note="Potassium channel inwardly rectifying transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01007"
FT DOMAIN 157..320
FT /note="Inward rectifier potassium channel C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17655"
FT SITE 136
FT /note="Role in the control of polyamine-mediated channel
FT gating and in the blocking by intracellular magnesium"
FT /evidence="ECO:0000256|PIRSR:PIRSR005465-1"
SQ SEQUENCE 338 AA; 38249 MW; DFAE09AAFC6459CC CRC64;
MSGALRRRLV SKDGHSNVRI DNVEGMVKLY LHDIWTTVVD MKWRYKLTLF VSTFLGTWFI
FGVLFYLIAM SNGDLGQAPE SNHTPCVMNV ATLTGAYLFS LESQTTIGYG FRHISEECPL
AIFTLVVQLV FTGLAEIFVT AAFLAKLARP KKRAETILFS QSAVVCRHQG KLCLMVRVAN
MRKSLLIQCQ LSGNLFSPYV TEEGEKILLH QEPVDFQLDS SQECPFLLLP LTFYHMLDES
SPLVSLTAES LKTRDFELVV TLNATMESTA STCQSRTSYL PQEVRWGYEF IPLLFSAPGG
GYITDFDYFD KIQESSDSSL LQKSVTEKLQ LEEEYRKE
//
