ID   A0A3B4CMD0_PYGNA        Unreviewed;       928 AA.
AC   A0A3B4CMD0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=BCAR3 adaptor protein, NSP family member {ECO:0000313|Ensembl:ENSPNAP00000011714.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000011714.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000011714.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_017549003.1; XM_017693514.1.
DR   AlphaFoldDB; A0A3B4CMD0; -.
DR   STRING; 42514.ENSPNAP00000011714; -.
DR   Ensembl; ENSPNAT00000018761.1; ENSPNAP00000011714.1; ENSPNAG00000017382.1.
DR   GeneID; 108425105; -.
DR   CTD; 8412; -.
DR   GeneTree; ENSGT00940000154130; -.
DR   OrthoDB; 2953960at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd09487; SAM_superfamily; 1.
DR   CDD; cd10337; SH2_BCAR3; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR   PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR   PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00454; SAM; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          6..64
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          227..326
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          654..922
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          399..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          581..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..429
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  104805 MW;  EAF507958A0235B9 CRC64;
     MKHLAISKWL SQLGLQQYCT LFDEEYDGVE DLLHLTEIDL LGLGVHSRLH RIHILSSIQV
     LCERETKREL RMMAEGRFAS LPRNLHVARQ CPLSSSMDLL SSRPAVVELP PPGYNSVSIH
     GTLPRKKKGA GSTPTRAWEM CGSLPHPSRC RLPSSPLIHN IIEEHQPFHV AREDCTVHRD
     VGGMDPTMEY VKFSRDKYIM DGAPEKLRRE LEEELKQCSE EPRSHAWYHG AIPRQVAENL
     VQRDGDFLIR DSLSSPGNYV LTCQWKNSPQ HFKINKEVVA MNEAYSRVQY LFEKEGFDSV
     PALVRYYVGN RQPVSEVVGA IIFQPINRAL PLRCLEEKYG VGSIRLEAGH RERKNQSSKR
     LSLNIMNGHV PDHTLGRGNL LSTKDKCGSQ PACLNHVQER RGPLKTHQSE SFLPLGSRPQ
     AQTHHMEIQS CPKSPVFRTG SEPALSPTVP RRMAFDTQPG EAIRGSDSQL CPKPPPKPSK
     VPSARLPRSP CLQPLTPVPQ VKPQKQWPSS HQQQQPVSLA SPEMNYCKLS PCSPAEWEMI
     SGLQANANGY VERLKTDEEK SKSGGTTKLD RSSYHHAIEA LENGSEEEDE EEEQRKAEQE
     APEKDKAKGF RRPIFETVSA FRPGDTDFRL LPAENKPLEM SVLKKAKELV VTQDPKTIAK
     HILQADCEVA RILNVSDEMK GQMGVTSGLE LVTLPHGRQL RQDLMERHNT MAIAVAVDIL
     GCTGSLDERA ATLNRIILVA LELKDTMGDL YAFSSIMKAL DMPQITRLDH TWTMLRRKYT
     QTAIIYEKSL KPFYKGLYEA SAEVPLSSAT VPLLMPLLTL MERPAVAFEG MELWESNDQG
     CEIMLRHLED ARAVARNADT YSYNSQRVLK DFRPNEDMLE ILKTDFQLRL LWGSRGAAVN
     QTERYDKFKL ILTALSRKLE PPVKHTEL
//