ID   A0A3B4CP33_PYGNA        Unreviewed;       594 AA.
AC   A0A3B4CP33;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSPNAP00000013812.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000013812.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000013812.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_017552885.1; XM_017697396.1.
DR   AlphaFoldDB; A0A3B4CP33; -.
DR   STRING; 42514.ENSPNAP00000013812; -.
DR   Ensembl; ENSPNAT00000037081.1; ENSPNAP00000013812.1; ENSPNAG00000019697.1.
DR   GeneID; 108427338; -.
DR   GeneTree; ENSGT00940000164067; -.
DR   OMA; LCKNALQ; -.
DR   OrthoDB; 4221421at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0140911; F:pore-forming activity; IEA:InterPro.
DR   GO; GO:0001909; P:leukocyte mediated cytotoxicity; IEA:InterPro.
DR   CDD; cd04032; C2_Perforin; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR037300; Perforin-1_C2.
DR   PANTHER; PTHR46096; PERFORIN-1; 1.
DR   PANTHER; PTHR46096:SF3; PERFORIN-1; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..594
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017437222"
FT   DOMAIN          33..378
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   DOMAIN          400..524
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   594 AA;  66441 MW;  8B5638388EBC030E CRC64;
     MGTYLTRSLT TVLLWPGLLV FLSLPLMQSC ENGKPRECAE AEFAPGSNLA GEGFDITTMQ
     RKGAFVIDMT RWKLKDKTCT LCRNPYMEGK KQKLPLSVVD WRPSQKCTMK LSSSLYQSSE
     SLLSSSTSAI ENNWGINLGI NVKKVDASLA MAGTNSKLAE YSMEKTKKDR FNFASQSISC
     GYYTYRVSNK RILHPEFKRS VNQLPKQYNA QFKPRFYKLI DNFGTHFITK VTLGGKVHSV
     TSIKQCQAAL QGLSADEVKI CLDVEASASV AGKANAKADM KHCDEAKSKT ESKGSFSSNF
     NDRFTEIYGG HTTEPELLFS ADKDPGAYKE WLSTLPQQPD IISYSLEALH ELLPPNNPVR
     KHLRQAVHDF ILEKSLWRNC SEPCMAGVKH NPKEPCICTC RNNPGVTPDC CPSKRGLARV
     KVTIERASGL WGDHTTQTDG YVKVFDKNKM EIGRTPVIYN NNSPHWGMPF DLGDIILTDH
     NSLRLEVWDE DSKWDDDLLG ACVVDVKAGE IQNFCKLDNG ELYYKIQVVC APSLAGPSCT
     DYVGSPMNNN LEKVYVSRHA RLVPKEMLLK MGVTLEEFHF TVNQKANNTA EIIL
//