ID A0A3B4CPU9_PYGNA Unreviewed; 714 AA.
AC A0A3B4CPU9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN Name=P3H3 {ECO:0000313|Ensembl:ENSPNAP00000014087.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000014087.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000014087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SIMILARITY: Belongs to the leprecan family.
CC {ECO:0000256|ARBA:ARBA00006487}.
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DR AlphaFoldDB; A0A3B4CPU9; -.
DR Ensembl; ENSPNAT00000021906.1; ENSPNAP00000014087.1; ENSPNAG00000020094.1.
DR GeneTree; ENSGT00940000159164; -.
DR OMA; KQCWREP; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR039575; P3H.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR14049; LEPRECAN 1; 1.
DR PANTHER; PTHR14049:SF15; PROCOLLAGEN-PROLINE 3-DIOXYGENASE; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 527..651
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 659..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 80165 MW; B6917310E549E858 CRC64;
MLGPTGVYIY IASSAPGSLS GLLPPYDELY YLGVRAYFKE EWERAAEHLE KSISTRQALR
RTRRRCHDEC STAGDDGADK MDSGSWDLLV LEWIQQRAEC IRFCLGQSVT PAGQLPVSMD
IEYEFGTRNP YNFLQVTYYK LGKLQKAATA AHTFFVANPS HLEMRNNIEK YRRMSGVTED
AFNDRERELE KHWEFYDAAT LAESTSDWTR AVERWKECVN ETLKQTDDCR AQCVVASQPF
PEETDSTEGV YEKAAALTLS LLSCKQMCVS LVSTRPGRIS PQEDFIPLQL EHLHIAQYKV
GDLKGAVKTL RSLLLFYPTD PDSLSNLQLY SESLEGDAEA QDTGPSQEIA SYVSRALAEK
KLLYFGVENL DFKFIDPDLW TPEGIVPESL RESWRAEREL LNEKLKEGEK WLEVDDSGFY
AGGPVPLVGV TITMDDLALN GTNRVVLDGV LSQSECDTVM QLASVAASVG DGYKGRRSPH
TPHEKFEGLT VLRALKLAQD GIVNQSDARL LHEMGERART LLHSYFRSHS ALYFAYTHLV
CRSAIPGHQD GRLDLSHPVH VDNCILEPET RQCWREAPAF THRDLSAILY LNEDFEGGEL
FFTDRDAKTV TARVKPSCGR LVGFTSGPVN PHGVTAVTAG RRCALALWFT TEKHHRDMER
EQAEAMWAAD GQSVVKEDQE DSDSALAPAR SGRSQTSKGR SKERERVTSG RDEL
//
