ID   A0A3B4CQ07_PYGNA        Unreviewed;       790 AA.
AC   A0A3B4CQ07;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000013443.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000013443.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3B4CQ07; -.
DR   STRING; 42514.ENSPNAP00000013443; -.
DR   Ensembl; ENSPNAT00000021075.1; ENSPNAP00000013443.1; ENSPNAG00000019514.1.
DR   GeneTree; ENSGT00950000182881; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        400..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        445..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        542..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        722..746
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          634..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..126
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        639..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   790 AA;  89898 MW;  C412AF367ABFEA1D CRC64;
     MGSMFRSEEV CLVQLFLQSG AAYHCVSELG ELGIVEFRDL NPNVNAFQRK FVSEVRRCEE
     LEKTFAFLEQ EITRSLPPSL RSSLQEAVPT PPAPQPRELL TIEEECERLA RELREVSRNR
     DSIRAQLNQL CQYRGVLTQT HLLTASQAPP HSFDPVGLVE NRQDVRLSFV AGVVHPWKVP
     AFERLLWRAC RGYIIVDFRE MQEKLEHPDS GEMVQWTVFL ISYWGDQIGQ KVKKICDCFH
     TQMFPYAESQ ADREEILNGL KTRIEDIKSV SKKTEQYLQQ LLMRAVAVLP QWRVRVQKCK
     AVQMVLNLCS PSVTEKCLIA EAWCPVRQLP ALQSALREGG RKSGSSVESF YNRLPATSSP
     PTLFPTNAFT AGFQNIVDAY GVASYREVNP AVYTIITFPF LFAVMFGDVG HGLIMALGAL
     WMVLEEKDPK LRNNTNEIWR MMFGGRYLIL LMGLFSIYTG AIYNECFSRG LTVFPSSWHV
     RPNLFSFGWW CSNTFRENTY LSLDPNVTGV FTGPYPFGID PIWGMANNHL TFLNSYKMKM
     SVIVGVIHMT FGVCLSFFNY VFVLICDTNA FIRDTEIRSI SDLQQRNSGS LNNQIGMTVQ
     KILVVVALCS VPVLLLGKPI HEYITYRRKR HQPTGERRPL LTENGSINTQ QGDVETSEEE
     EQEFDGANVF MHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWV MVMRFSFRKT
     EYVGSVIMAV VFAFFAVLTI SILLVMEGLS AFLHALRLHW VEFQNKFYSG TGYKLTPFAF
     KSLISVSAAN
//