ID A0A3B4CQK9_PYGNA Unreviewed; 376 AA.
AC A0A3B4CQK9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000013650.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000013650.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC Golgi. {ECO:0000256|RuleBase:RU369013}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC protein {ECO:0000256|RuleBase:RU369013}.
CC -!- SIMILARITY: Belongs to the ERGIC family.
CC {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017545793.1; XM_017690304.1.
DR AlphaFoldDB; A0A3B4CQK9; -.
DR STRING; 42514.ENSPNAP00000013650; -.
DR Ensembl; ENSPNAT00000037013.1; ENSPNAP00000013650.1; ENSPNAG00000019558.1.
DR GeneID; 108419686; -.
DR CTD; 51290; -.
DR GeneTree; ENSGT00530000063113; -.
DR OMA; EDTWWEL; -.
DR OrthoDB; 506854at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR InterPro; IPR045888; Erv.
DR InterPro; IPR012936; Erv_C.
DR InterPro; IPR039542; Erv_N.
DR PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR PANTHER; PTHR10984:SF30; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2; 1.
DR Pfam; PF07970; COPIIcoated_ERV; 1.
DR Pfam; PF13850; ERGIC_N; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU369013};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369013};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369013};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369013}; Transport {ECO:0000256|RuleBase:RU369013}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369013"
FT DOMAIN 13..98
FT /note="Endoplasmic reticulum vesicle transporter N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13850"
FT DOMAIN 167..330
FT /note="Endoplasmic reticulum vesicle transporter C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07970"
SQ SEQUENCE 376 AA; 42445 MW; 7E8A3C12A415AAC2 CRC64;
MRRLSRKKAL NFVKELDAFP KVPESYVETS ATGGTVSLVA FTAMALLAFF EFFVYRDTWM
KYEYEVDKDF SSKLRINIDI TVAMRCQFVG ADVLDLAETM VASDGLQYEP VVFELSPQQR
LWHRTLLLVQ NRLREEHSLQ DVIFKSVMKG GPTALPPRED DPTQPLNACR IHGHLYVNKV
AGNFHITVGK AIPHPRGHAH LAALVSHETY NFSHRIDHLS FGEEIPGILN PLDGTEKVCT
DHNQMFQYFI TIVPTKLETY KVSADTHQYS VTERERVINH AAGSHGVSGI FMKYDVSSLR
VLVTEQHMPL WQFLVRLCGI IGGIFSTTGM LHGLVGFCVD VVCCRFKLGV YKPKGISLLD
GHVNSKTHLL SENNEH
//
