ID A0A3B4CTS2_PYGNA Unreviewed; 1314 AA.
AC A0A3B4CTS2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSPNAP00000015487.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000015487.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000015487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPNAT00000023695.1; ENSPNAP00000015487.1; ENSPNAG00000021620.1.
DR GeneTree; ENSGT00940000158324; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 198..293
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 408..511
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 562..709
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 748..987
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 985..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1191
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1241
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1314 AA; 150101 MW; B308D784A3C5CB5F CRC64;
MQTPQHGYDF SSEENSPKWR GLFIQALRKV QLQVHPNLSA KEDALQHIEE LILQLLNMLC
VSQPRTVPDV EERIQKTFPY PIDKWAMADA QAAIEKRKRR NPLLLPVDKI HPLLKEVLGY
KIDYHVSLYI VAVLEYISAD ILKLAGNYVG NIRHYEISQQ DIKVSMCADK VLMDMFDQEE
VGLVSQCVEE VSSTGELTYD DLVRLEIAEE RQYLRELDLI IKVFRKAFLS NSKLFTAQDV
EVVFSNILEV HELTVKLLGL IEDAVEMTAD GSPHPLVGSC FEDLAEEQAF DPYETLSQDI
LSKEFHEHFS SLMSRPTVAL HFQQLQERSE DQDDRECLKQ AQTALLILQS SIDRIYGKHQ
PRRKPGEPLY RLYSRPVRSK QLAIKRMNEI QRSIDGWEGK DIGQCCSQFI LEGPLVRAGA
KHERHNFLFD GLMISCKANQ SSRLPGTGSG AEFRLKEKFV LRKYRIADRE DTSELRFAFE
LVGREESSAV FCARSAEEKN AWMAALVTLQ YRSTLDRMLD TELQREEQAQ PLRLPSPDVY
RFTVQDSEEN IVFEEHTQSK TGIPIIKAGT VDKLIERLTY HMYADPNFVR TFLTTYRSFC
KPQDLLTLLI ERIEIPEPEQ SEADLQALWN GDQPMAAELQ RFRREYVQPV QLRVLNVFRQ
WVEHHFYDFE NDPELRCRLE EYITNTLQLR GKSMRKWVES INKIIKRKIQ TQPNGVSHNI
TFESPPPPIE WHISRPGQVD TFELMTLHPI EIARQLTLLE SDLYRAVRPS ELVGSVWTKE
DKEKNSPNLL RMIRHTTNLT LWFEKCIVEA ENLDERVAVF SRIIDILQVF QELNNFNGVL
EIVSAINSVP VYRLDHTFEA VPERKRKILE EAVELSQDHF KKYLAKLKSI NPPCVPFFGI
YLTNILKTEE GNPDFLKRHG HELINFSKRR KVAEITGEIQ QYQNQPYCLR VEHEIRKFFE
NLNPMGSMSE KEFSDYLFNK SQEIEPRNCK QPPRFPRKST YSLKSPGVRP VRQASGSSGT
VRVHPVPLER EPPHKITFRS IAETEVESTA SLPTSPNTPT PPQSASSDLS SVFMDHELSS
TYGEQSVRYI AFILFHSVSC GSLHQLGDEL LKPPPLPPRR KDTFSDNKLS SRSEDSPPAI
PPRLPPPLPR LQPRVPTFNG PADGPLPSPP PPPPRDPIPD SLPPLPQRPP ESFINYPISA
AVSPGGRIQW DFSSSPSSPC TPPGTPSPRL APPPGTPSPR VPRRSCPLSA SQTSLCHLPL
PITAPPIPPR HNSTSALPKL PPKTYKRELS HPTHTLSQPS IHTLSLVDNA DSSQ
//
