ID A0A3B4CWQ7_PYGNA Unreviewed; 1140 AA.
AC A0A3B4CWQ7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Potassium voltage-gated channel subfamily H member 2 {ECO:0000256|ARBA:ARBA00013838};
DE AltName: Full=Ether-a-go-go-related gene potassium channel 1 {ECO:0000256|ARBA:ARBA00030015};
DE AltName: Full=Voltage-gated potassium channel subunit Kv11.1 {ECO:0000256|ARBA:ARBA00031970};
GN Name=KCNH2 {ECO:0000313|Ensembl:ENSPNAP00000016532.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016532.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000016532.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. H (Eag) (TC
CC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00007076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4CWQ7; -.
DR Ensembl; ENSPNAT00000025065.1; ENSPNAP00000016532.1; ENSPNAG00000022778.1.
DR GeneTree; ENSGT00940000159846; -.
DR OMA; TEDCEKR; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF506; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..144
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 721..821
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 173..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1012..1039
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 188..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 128259 MW; A36C504F27BA3350 CRC64;
MPVRRGHVAP QNTFLDTIIR KFESQSRKFV IANARVENCA IIFCNDGFCH MCGYTRAEIM
QKPCTCNFLY GPHTKRLAIA QMAQALLGSE ERKVEITLYR KDGVCFLCLV DVVPVKNEDG
AVIMFILNFE VMTDDKLRNP NQELNHRLPL PWLRRIRLRL PLLQSHSKSR LSLKDDAEAG
GGEVGVSGSV HPTTTATPSS SLWPEDHRTL LSSEPVPHPS TPSHHSTLPL GQSSPRPQRL
NPDASASNCS LTHSRSRESF HSMRRASSVD DIEAMRPEWD RKHRSRPSMN NKSSILNSTS
DSDLMRYRTI SKIPQITLNF VDFKPDPLIA LPPGEMDIIA PCKLIDRTHN VTEKVTQVLS
LGADVLPEYK LQAPRIHKWT VLHYSPFKAV WDWLILLLVI YTAILTPYSA AFLLNDVEES
SMSGCGYCSP LSVVDLIVDI MFIIDILINF RTTYVNANDE VVSHPLRIAV HYFKGWFLID
MVAAIPFDLL IYRNGEETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL
IAHWLACIWY AIGNVERSRA IGWLHTLGDQ LGKPYNISAP GSGPTIKDKY VTALYFTFSS
LTSVGFGNVS PNTNSEKIFS ICVMLIGSLM YASIFGNVSA IIQRLYSGTA RYHTQMLRVR
EFIRFHQIPN PLRQRLEEYF QHAWSYTNGI DMNAVLKGFP ECLQADICLH LNRTLLQNCK
AFKGCTKGCL RALAMKFKTT HAPPGDTLVH AGDVLTALYF ISRGSIEILR GDVVVAILGK
NDIFGEPINL YARPGKSNAD VRALTYCDLH KIHREDLLEV LDMYPEFSDH FWSNLEITFN
LRDTNMIPGS PSSDDSDCIG FNKLRKRKLS FRRRTEKDAG EIKKNQKPLR RNRKQAMSNQ
NEGLKSDWEG PRSSISSHSS GDEREEPFHT SPEPPTALLE LSQAQATSVN FNDNPEGEGD
PKTGNTCNAL SGALSGVSNI FSFWGESRGR QYQELPRCNL PSPPPQLNTP LHSISKQQRN
QLENRLDMLQ KQLNRLETRM STDISAIMQL LQRQMSLVPP AYSTVSSPPQ VSPESLQCLT
ELLPSEIPIL SPGDVPLQSL SLRPHPQPPD TDTQRRFSLQ EQQSPLDSRT PQRHSSDPGS
//
