ID A0A3B4CX47_PYGNA Unreviewed; 453 AA.
AC A0A3B4CX47;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Lipase member H-like {ECO:0000313|Ensembl:ENSPNAP00000015114.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000015114.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000015114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR RefSeq; XP_017572469.1; XM_017716980.1.
DR AlphaFoldDB; A0A3B4CX47; -.
DR STRING; 42514.ENSPNAP00000015114; -.
DR Ensembl; ENSPNAT00000023230.1; ENSPNAP00000015114.1; ENSPNAG00000021132.1.
DR GeneID; 108438884; -.
DR CTD; 100003046; -.
DR GeneTree; ENSGT00940000166938; -.
DR OMA; KISMRIN; -.
DR OrthoDB; 3428256at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF186; LIPASE H-RELATED; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..453
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017452262"
FT DOMAIN 39..329
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT ACT_SITE 159
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 183
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 253
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 197
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 199
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 202
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ SEQUENCE 453 AA; 51241 MW; 2952084DBF90E2BE CRC64;
MGLWKFLGLV GFFTLCRAGQ DNKCDNFSDL NFHETFIGTN LYVRLLLYTR ANLDCGQELP
HHNFTKELLF DVKKPTTFVI HGYRPTGAPP IWINHIVHLL AAQVDMNILV VDWNRGAANL
NYFIAVTNTR RTAINITGFI ERMRDEGASL ESIHLIGVSL GAHVAGFIGA MLGGKIGRIT
GLDPAGPMFA GVPPDERLDP TDAQFVDVLH TDMNSFGLKG THGHIDFYAN GGLDQPGCPK
TIFSGKSYFV CDHQRAIFLY LCALNHTCNI TAYPCSSYSD FLNGQCLQCE AFKPASCPVL
GYDMTPWKNT LLKLGQTRVY FSTSADPPYR KTSYRVDIVT WNQYLRWGVV TLRLHSGKNV
TETRIDHKLL RFEQYTATRM LAQFDEDLYP VQKISLRIIT GNVIGPRYKL RLIRIRITPL
DQPDRPLMCR YDLIMEENAE ITFKPLPCDE SRL
//
